{"id":"W3046930080","doi":"10.2174/0929867327666200730215752","title":"Discovery and Investigation of 1-[4-(2-Aminoethoxy)Phenylcarbonyl]- 3,5-Bis-(Benzylidene)-4-Piperidones as Candidate Antineoplastic Agents: Our Last 15 Years Study","year":2020,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Caspase; Drug; Chemistry; Metabolic stability; Pharmacology; Mechanism of action; Pharmacokinetics; Drug discovery; Stereochemistry; Antimycobacterial; Toxicity; Computational biology; Combinatorial chemistry; Apoptosis; Biology; Biochemistry; Medicine; In vitro; Programmed cell death; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002946728,0.0007922665,0.002403247,0.00005636996,0.00007341512,0.00007320249,0.0005352563,0.0004299324,0.0001591419],"category_scores_gemma":[0.001251843,0.0005944835,0.0003696778,0.0002955539,0.0002402062,0.0001201673,0.0004023145,0.001003981,0.00001213495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206322,"about_ca_system_score_gemma":0.0004587397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005156642,"about_ca_topic_score_gemma":0.000003902482,"domain_scores_codex":[0.9966269,0.0001239448,0.001087157,0.001057164,0.0006875772,0.0004172518],"domain_scores_gemma":[0.997551,0.0004803386,0.001025748,0.0005025858,0.00007326635,0.0003671052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001137071,0.0008131426,0.01030411,0.08563587,0.0008126553,0.0002923939,0.0004182011,3.54536e-7,0.009745432,0.000004593174,0.0006370125,0.8912225],"study_design_scores_gemma":[0.003555247,0.0006308614,0.003619808,0.09204777,0.01067676,0.000505543,0.00549776,0.00005359804,0.02239869,0.00008637438,0.8566821,0.004245523],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2500473,0.7487273,0.000004258209,0.00002324373,0.0002976446,0.0002755196,0.000238086,0.00006226517,0.0003243993],"genre_scores_gemma":[0.3361177,0.662363,0.00000795202,0.000009323539,0.0009662923,0.00006171076,0.0003150545,0.0000483137,0.0001106093],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.886977,"threshold_uncertainty_score":0.9996507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0631706600326778,"score_gpt":0.3377432316267064,"score_spread":0.2745725715940286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}