{"id":"W3046930080","doi":"10.2174/0929867327666200730215752","title":"Discovery and Investigation of 1-[4-(2-Aminoethoxy)Phenylcarbonyl]- 3,5-Bis-(Benzylidene)-4-Piperidones as Candidate Antineoplastic Agents: Our Last 15 Years Study","year":2020,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Caspase; Drug; Chemistry; Metabolic stability; Pharmacology; Mechanism of action; Pharmacokinetics; Drug discovery; Stereochemistry; Antimycobacterial; Toxicity; Computational biology; Combinatorial chemistry; Apoptosis; Biology; Biochemistry; Medicine; In vitro; Programmed cell death; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358307,0.0004005981,0.0003937311,0.0005791362,0.0001201256,0.0003235167,0.0003122224,0.0003024138,0.001444018],"category_scores_gemma":[0.0001755339,0.0001551425,0.0001753678,0.0006184935,0.0001923903,0.0005645023,0.0002404039,0.0006555651,0.0008143224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550602,"about_ca_system_score_gemma":0.0004583893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139977,"about_ca_topic_score_gemma":0.001001639,"domain_scores_codex":[0.9999439,0.000007022153,0.000005411519,0.00001256549,0.0000224681,0.000008778394],"domain_scores_gemma":[0.999951,0.00001202176,0.00001106571,0.00000233072,0.00001640065,0.000007093307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150425,0.0001678569,0.0002902523,0.0149637,0.00007809392,0.0003679541,0.0001301251,0.001387502,0.06326085,0.008467354,0.008855384,0.9019159],"study_design_scores_gemma":[0.00003168591,0.0004402116,0.001527618,0.001131875,0.0001168768,0.001756302,0.00006563745,0.0005138741,0.02436253,0.001670179,0.968361,0.00002224661],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003284038,0.9925151,0.0009352558,0.0002000123,0.0001444189,0.00001285305,0.00002575256,0.00001654039,0.00286594],"genre_scores_gemma":[0.01123497,0.9853924,0.000983924,0.0001804163,0.00009178026,0.00001280588,0.00004790296,0.000002729151,0.002053061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001444018,"threshold_uncertainty_score":0.004830718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0631706600326778,"score_gpt":0.3377432316267064,"score_spread":0.2745725715940286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}