{"id":"W3046932783","doi":"10.1093/noajnl/vdaa073.000","title":"04. ASSESSMENT OF EFFICACY AND SAFETY OF OSIMERTINIB FOR PATIENTS WITH INTRACRANIAL METASTATIC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS","year":2020,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Osimertinib; Medicine; Internal medicine; Oncology; Meta-analysis; Lung cancer; Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810892,0.0003633381,0.008361778,0.0001452361,0.00005000202,0.000005030651,0.00008531674,0.00004458216,0.00003656108],"category_scores_gemma":[0.0004474295,0.0001962999,0.0007246847,0.0003640106,0.0001547788,0.00007040308,0.000035857,0.0001340092,2.802008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006039879,"about_ca_system_score_gemma":0.0004562329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001502808,"about_ca_topic_score_gemma":0.000004562147,"domain_scores_codex":[0.9975587,0.000386179,0.001202505,0.000468701,0.0002391463,0.0001447645],"domain_scores_gemma":[0.9959774,0.001822036,0.001524397,0.0003057488,0.0002046995,0.0001657349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001326823,0.0004374393,0.00007688206,0.849302,0.1336511,0.00002463081,0.00002673972,0.000002544366,9.336492e-8,0.00004923004,0.00001127245,0.01628539],"study_design_scores_gemma":[0.001593171,0.001564001,0.0001170498,0.01219175,0.9315131,0.00001315153,0.000006806941,0.0000075015,7.876162e-8,0.000005718578,0.0528627,0.0001249885],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005474079,0.9892704,0.0003368228,0.0003312419,0.00002825766,0.00894042,0.001050867,0.00001043187,0.00002604669],"genre_scores_gemma":[0.0002200729,0.9936212,0.003880746,0.0002768195,0.000009213006,0.001629611,0.0003168904,0.0000290958,0.00001629841],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8371103,"threshold_uncertainty_score":0.8004876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03902449503705761,"score_gpt":0.4208557410485946,"score_spread":0.381831246011537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}