{"id":"W3046932783","doi":"10.1093/noajnl/vdaa073.000","title":"04. ASSESSMENT OF EFFICACY AND SAFETY OF OSIMERTINIB FOR PATIENTS WITH INTRACRANIAL METASTATIC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS","year":2020,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Osimertinib; Medicine; Internal medicine; Oncology; Meta-analysis; Lung cancer; Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01712482,0.002671139,0.01639569,0.007990821,0.0006820594,0.003918204,0.002125085,0.002724506,0.006025892],"category_scores_gemma":[0.03366961,0.001383191,0.0600597,0.007216231,0.0008970132,0.002366576,0.001459558,0.002258497,0.0006117331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003056124,"about_ca_system_score_gemma":0.003456188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005996122,"about_ca_topic_score_gemma":0.0120034,"domain_scores_codex":[0.98404,0.007760542,0.004381605,0.001646209,0.001771812,0.0003998972],"domain_scores_gemma":[0.9808714,0.01330535,0.003690555,0.0005245626,0.001344272,0.0002640041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001463406,0.00001767114,0.003356462,0.3056412,0.6795135,0.0000736504,0.00004668668,0.0004299322,0.0001277894,0.000143662,0.0006043959,0.008581658],"study_design_scores_gemma":[0.0008624552,0.0001501259,0.003089189,0.02102407,0.9727439,0.00008737641,0.00003069237,0.0002159695,0.00008737815,0.0002449268,0.001441058,0.0000228302],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006371542,0.9889632,0.0009755821,0.0004098082,0.000234261,0.0006496377,0.001639489,0.00005014259,0.0007063356],"genre_scores_gemma":[0.3546408,0.6317249,0.004859518,0.00209308,0.0005049243,0.002978383,0.00214778,0.00009152467,0.0009591352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01712482,"threshold_uncertainty_score":0.09056574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03902449503705761,"score_gpt":0.4208557410485946,"score_spread":0.381831246011537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}