{"id":"W3046935819","doi":"10.1158/1538-7445.pedca19-a54","title":"Abstract A54: Parallel targeting of RAF/MEK/ERK pathway in RAS-mutant embryonal rhabdomyosarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Trametinib; Neuroblastoma RAS viral oncogene homolog; Embryonal rhabdomyosarcoma; MAPK/ERK pathway; MEK inhibitor; Cancer research; HRAS; Rhabdomyosarcoma; PI3K/AKT/mTOR pathway; Cancer; Mutant; Biology; Targeted therapy; Medicine; Signal transduction; KRAS; Cell biology; Pathology; Genetics; Sarcoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356807,0.0003253918,0.0003261695,0.0002782394,0.0002261679,0.0002462667,0.0002739893,0.0003836462,0.005056967],"category_scores_gemma":[0.00007106065,0.0001655805,0.00042849,0.0001576511,0.0001842661,0.0001769193,0.0002324562,0.0006376092,0.001064166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572214,"about_ca_system_score_gemma":0.0002719093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007463194,"about_ca_topic_score_gemma":0.001275758,"domain_scores_codex":[0.9998195,0.00001576116,0.00002338702,0.00004671967,0.00006029149,0.00003437144],"domain_scores_gemma":[0.9999551,0.000005810818,0.000007804596,0.000006877601,0.000008496528,0.00001599636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336524,0.00006304438,0.00007564769,0.00003952605,0.000007162791,0.00007209423,0.00001053552,0.00009796282,0.9968238,0.000145339,0.0003196383,0.00221159],"study_design_scores_gemma":[0.00005582559,0.0007590516,0.001596447,0.000006458676,0.00002439195,0.0003376286,0.00001555112,0.0005773324,0.9902975,0.0000486756,0.006274988,0.000006051733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775746,0.00167762,0.007664645,0.0004455179,0.0003404331,0.0002871613,0.002240672,0.0005724784,0.009196886],"genre_scores_gemma":[0.9694875,0.001077406,0.008923657,0.0001560966,0.00001967984,0.0002447322,0.001611931,0.0001004882,0.01837858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005056967,"threshold_uncertainty_score":0.01691729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137513628836671,"score_gpt":0.3972506261201197,"score_spread":0.2834992632364526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}