{"id":"W3046948275","doi":"10.1038/s42255-020-0256-z","title":"Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy","year":2020,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Cancer Institute; National Institutes of Health; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft","keywords":"Effector; Conditioning; Cytotoxic T cell; CD8; Adoptive cell transfer; Cell therapy; Immunology; Biology; Cell; T cell; Immune system; Biochemistry; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003842724,0.0002880909,0.0009078197,0.0001779171,0.00007575189,0.00002467634,0.0002425192,0.0004110629,0.002055948],"category_scores_gemma":[0.0001705928,0.0002309917,0.0004659501,0.0005826686,0.0001172663,0.00009371906,0.00004640102,0.001003077,0.00004665731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002040719,"about_ca_system_score_gemma":0.0001452311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001074227,"about_ca_topic_score_gemma":6.392796e-7,"domain_scores_codex":[0.9980096,0.0001420318,0.0003470481,0.0004580943,0.0006159273,0.0004273348],"domain_scores_gemma":[0.998351,0.0003472877,0.000166845,0.0003610192,0.0004726376,0.000301205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001527824,0.0001462426,0.00009328906,0.0001512693,0.0002783867,0.000008531209,0.000853512,0.000008839982,0.9738877,0.001014204,0.005794162,0.01623597],"study_design_scores_gemma":[0.004231296,0.0002445462,0.001869167,0.0000130178,0.0001384768,0.000002669693,0.00005829054,0.00008989184,0.6091331,0.00006005507,0.3840328,0.0001267062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8920398,0.08804505,0.001303163,0.003121235,0.001359123,0.006420478,0.0006292559,0.0002169252,0.006864986],"genre_scores_gemma":[0.9855545,0.001312535,0.004986724,0.003976442,0.001736188,0.0002035386,0.0001667653,0.0001054345,0.001957858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3782386,"threshold_uncertainty_score":0.9988563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02084328251154539,"score_gpt":0.3125214294409055,"score_spread":0.2916781469293601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}