{"id":"W3047005388","doi":"10.1158/1538-7445.pedca19-b56","title":"Abstract B56: A CRISPR/Cas9 domain screen identifies a small motif in the PAX3-FOXO1 transactivation domain relevant for tumor maintenance in alveolar rhabdomyosarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Druggability; Alveolar rhabdomyosarcoma; Transcription factor; Biology; Transactivation; Fusion protein; Carcinogenesis; Computational biology; Genetics; Cancer research; Rhabdomyosarcoma; Gene; Medicine; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686481,0.0004240171,0.000433781,0.0003300577,0.0001879633,0.0002586391,0.0003186961,0.0004508316,0.002597411],"category_scores_gemma":[0.00012136,0.0001351669,0.0003690275,0.0001983827,0.0002142194,0.00007914234,0.0003138818,0.0004895395,0.0009314527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245955,"about_ca_system_score_gemma":0.0002280957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252637,"about_ca_topic_score_gemma":0.001699483,"domain_scores_codex":[0.9997757,0.00002324739,0.00002649768,0.00005624762,0.00008148685,0.00003680502],"domain_scores_gemma":[0.9998853,0.00002861715,0.00002462738,0.0000125301,0.00001035379,0.0000384505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004181124,0.00001715873,0.00006937478,0.00001429515,0.000003451744,0.00006801835,0.000004398144,0.00006530945,0.9992238,0.00003143015,0.00002726536,0.0004336826],"study_design_scores_gemma":[0.00001607094,0.0001642758,0.00243748,0.000006078731,0.0000190571,0.0003894092,0.00001908944,0.001450576,0.9936098,0.00002686926,0.001853145,0.000008058395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826446,0.0005464201,0.01029216,0.0001291255,0.00005290974,0.0001288743,0.002929451,0.000404645,0.00287166],"genre_scores_gemma":[0.9870911,0.0002324053,0.006162906,0.00006531008,0.000003933368,0.00004576756,0.001951551,0.00009841863,0.004348773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002597411,"threshold_uncertainty_score":0.008689225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07660945267326966,"score_gpt":0.3620230747456486,"score_spread":0.285413622072379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}