{"id":"W3047040853","doi":"10.1158/1538-7445.pedca19-b17","title":"Abstract B17: A <i>C19MC</i>-LIN28A-MYCN oncogenic circuit driven by hijacked super-enhancers is a distinct therapeutic vulnerability in ETMRs—a lethal brain tumor","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Epigenetics; Biology; Enhancer; Cancer research; microRNA; Carcinogenesis; Embryonic stem cell; Downregulation and upregulation; Neuroblastoma; Chromatin; Epigenomics; Cell biology; Gene; Transcription factor; DNA methylation; Genetics; Gene expression; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006856376,0.0002780728,0.000200627,0.0001635168,0.0001614702,0.0002326012,0.0001702858,0.0002713118,0.003045096],"category_scores_gemma":[0.00005100605,0.00009461479,0.0002170637,0.00007588103,0.0002136532,0.0001232582,0.0001857661,0.0007014875,0.0007271965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903587,"about_ca_system_score_gemma":0.0001600605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195651,"about_ca_topic_score_gemma":0.0005687618,"domain_scores_codex":[0.9999189,0.000005909535,0.000004591049,0.00002506368,0.00002078954,0.00002468438],"domain_scores_gemma":[0.9999471,0.00000650384,0.00001276648,0.000007232415,0.000003632704,0.00002291073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008169973,0.00003030609,0.0002591709,0.00001392445,0.000004670622,0.000199424,0.000006131454,0.00004707374,0.9978599,0.0002527412,0.0001280973,0.001116862],"study_design_scores_gemma":[0.000023841,0.0005073849,0.004949221,0.000004166663,0.00001959652,0.002487871,0.0000238096,0.00108678,0.9851842,0.0001749991,0.005533361,0.000004818814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891387,0.0009644944,0.004265752,0.0002190865,0.00006393817,0.00004746862,0.0008562243,0.0002904125,0.004154003],"genre_scores_gemma":[0.9928054,0.0002570873,0.001493208,0.00009847391,0.000008872918,0.00003579352,0.0006856843,0.00006912072,0.004546304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003045096,"threshold_uncertainty_score":0.01018679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08457749333775737,"score_gpt":0.3882274919632356,"score_spread":0.3036499986254783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}