{"id":"W3047049660","doi":"10.1038/s41467-020-17577-8","title":"A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; National Heart, Lung, and Blood Institute; Lloyd's Tercentenary Research Foundation; National Institutes of Health; Government of Canada; European Respiratory Society; University of Ottawa","keywords":"Lung; Genetic enhancement; Pulmonary surfactant; Respiratory distress; Biology; Vector (molecular biology); Surfactant protein C; Immunology; Flow cytometry; Transgene; Homeostasis; Medicine; Pathology; Gene; Cell biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003599504,0.0007709457,0.0006524912,0.0007880736,0.0002863903,0.0004823729,0.0004462688,0.0009639555,0.001677096],"category_scores_gemma":[0.000189657,0.000236059,0.0003395709,0.000238073,0.0004941245,0.0004846744,0.0002221425,0.001577975,0.0003644061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827048,"about_ca_system_score_gemma":0.0004348163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179372,"about_ca_topic_score_gemma":0.001149151,"domain_scores_codex":[0.999731,0.00004835005,0.00003188984,0.0000652416,0.00006004849,0.00006333693],"domain_scores_gemma":[0.9997075,0.00004427755,0.00006489066,0.00002913796,0.00002840947,0.0001257226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005413242,0.0004214693,0.00012296,0.00004317558,0.000009420925,0.00009891465,0.00003092227,0.000192334,0.9945972,0.0001467289,0.0002129518,0.003582582],"study_design_scores_gemma":[0.0002706727,0.01176247,0.002827084,0.00003611248,0.00006627081,0.0006658278,0.00006690558,0.003548739,0.9766845,0.0002200123,0.003826582,0.00002491487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887542,0.001703821,0.005532439,0.0006189565,0.0002132348,0.0001022661,0.0007110767,0.0007207463,0.00164337],"genre_scores_gemma":[0.9780415,0.001986585,0.007219737,0.000270084,0.00005856136,0.000215333,0.001440633,0.0001344897,0.01063307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677096,"threshold_uncertainty_score":0.005610466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08438491177010649,"score_gpt":0.3956565944071107,"score_spread":0.3112716826370042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}