{"id":"W3047058424","doi":"10.1158/1538-7445.pedca19-b51","title":"Abstract B51: Adaptation to oncogene-induced metabolic stress by MondoA (MLXIP) drives common acute lymphoblastic leukemia (cALL) malignancy","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency","funders":"","keywords":"Cancer research; Downregulation and upregulation; Gene knockdown; Transcription factor; Biology; Chemistry; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273148,0.0002699003,0.0003004459,0.0004168615,0.0003313304,0.0006130166,0.0001978308,0.0002847282,0.004192671],"category_scores_gemma":[0.000157656,0.0002036843,0.000323513,0.0003225586,0.0003618715,0.0001719828,0.000418049,0.0007760101,0.001020153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004493767,"about_ca_system_score_gemma":0.000215008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000908617,"about_ca_topic_score_gemma":0.001676747,"domain_scores_codex":[0.9997436,0.00002899221,0.00002144596,0.00007817601,0.00006343034,0.00006435007],"domain_scores_gemma":[0.999851,0.00001776571,0.00003966238,0.00001612926,0.00001042651,0.00006505551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300908,0.00001565142,0.001041523,0.00003646969,0.0000053446,0.00007893689,0.00002827843,0.00004045351,0.997192,0.0001248503,0.0001251723,0.001181384],"study_design_scores_gemma":[0.00005544657,0.0005025317,0.07183253,0.00004129534,0.00007439722,0.001746765,0.0004904657,0.002458379,0.9059234,0.0002814317,0.01657027,0.00002313421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923267,0.0009873259,0.00240405,0.0001318759,0.00004114944,0.00003367182,0.002136628,0.0002335743,0.001704976],"genre_scores_gemma":[0.993924,0.0003414025,0.001010961,0.00008564433,0.000005752112,0.00003970385,0.001847183,0.0000726193,0.002672752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004192671,"threshold_uncertainty_score":0.01402593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04940880904559213,"score_gpt":0.354361155073127,"score_spread":0.3049523460275349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}