{"id":"W3047075759","doi":"10.1016/j.canlet.2020.07.015","title":"Angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient hypoxia and improves tumour response to radiation","year":2020,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC","keywords":"Telmisartan; Hypoxia (environmental); Losartan; Perfusion; Angiotensin II; Cancer research; Medicine; Pharmacology; Chemistry; Internal medicine; Pathology; Receptor; Oxygen; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331442,0.0001178898,0.0001290424,0.00002397807,0.00008571091,0.00001055751,0.00009007879,0.00005040019,0.00001025384],"category_scores_gemma":[0.00005040197,0.00009542959,0.00003992454,0.000127229,0.00005199625,0.000003494347,0.00005090938,0.00005758534,0.000002683215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001958231,"about_ca_system_score_gemma":0.0001558704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001146479,"about_ca_topic_score_gemma":0.00002688998,"domain_scores_codex":[0.9992492,0.00004642418,0.0001806345,0.0002559763,0.0001058256,0.0001620008],"domain_scores_gemma":[0.9996464,0.00000871728,0.00005797249,0.0001255881,0.0000545173,0.0001068581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007155979,0.000007121101,0.00004060588,0.000009303297,0.0000360224,1.375578e-7,0.003175325,0.00003127116,0.9421706,7.724889e-7,0.03771255,0.01610075],"study_design_scores_gemma":[0.0002825826,0.00007142282,0.006482972,0.000008284259,0.00001396509,7.302885e-7,0.00005893871,0.000005219129,0.5324729,1.74153e-7,0.460515,0.00008782862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751467,0.002762923,0.0001759805,0.02118098,0.0004600312,0.0002379269,0.0000189757,0.000007040825,0.000009454886],"genre_scores_gemma":[0.98688,0.0002191352,0.001207784,0.01073734,0.0007776956,0.00002733805,0.00001588169,0.00001945555,0.0001153494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4228024,"threshold_uncertainty_score":0.3891506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01118236407605014,"score_gpt":0.2324916803646674,"score_spread":0.2213093162886172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}