{"id":"W3047081808","doi":"10.1016/j.cell.2020.07.005","title":"Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1045,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Juno Therapeutics; U.S. Food and Drug Administration; Stanford Bio-X; Defence Science and Technology Laboratory; Hamilton Health Sciences Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Oxford; Parker Institute for Cancer Immunotherapy; U.S. Department of Defense; Silicon Valley Community Foundation; University of Bern; National Institute of Allergy and Infectious Diseases; Celgene; National Heart, Lung, and Blood Institute; Pfizer; Bill and Melinda Gates Foundation; National Cancer Institute; Kenneth Rainin Foundation; Cancer Research Institute; Cancer Research UK; National Science Foundation","keywords":"Biology; Colorectal cancer; Immunity; Cellular immunity; Cancer; Immunology; Cancer research; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007719519,0.00009918885,0.0001447965,0.0002241439,0.0001543297,0.0003946793,0.00007762141,0.0001134944,0.0003222994],"category_scores_gemma":[0.0001591556,0.0001177981,0.00006426835,0.0001384938,0.0001746141,0.0001928193,0.0002790414,0.0001492092,0.0001146632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222978,"about_ca_system_score_gemma":0.0001914607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005621368,"about_ca_topic_score_gemma":0.001471073,"domain_scores_codex":[0.999908,0.00001729647,0.000004189447,0.00002404988,0.00002148068,0.0000250874],"domain_scores_gemma":[0.999897,0.0000151054,0.00004130557,0.00001007656,0.00001656305,0.00001988808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001876246,0.00001386653,0.01622879,0.00002093973,0.000006021837,0.00007631975,0.00006703308,0.0005004603,0.9784393,0.0003866052,0.00005021647,0.004022808],"study_design_scores_gemma":[0.00002726179,0.0004236832,0.37553,0.00001688879,0.00006077962,0.001144477,0.0007824114,0.01137139,0.6047493,0.0008691744,0.00500453,0.00002010559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977447,0.0001851173,0.001544207,0.00001638863,0.000001250494,0.000005745791,0.00004436327,0.00001816756,0.000440113],"genre_scores_gemma":[0.9986802,0.00006213199,0.001028311,0.00000751305,0.000001296131,0.000006452782,0.00003943636,0.00000288121,0.0001718406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005621368,"threshold_uncertainty_score":0.001612902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02454438960022445,"score_gpt":0.2543532474892553,"score_spread":0.2298088578890309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}