{"id":"W3047091817","doi":"10.1124/dmd.120.090886","title":"Human Amyloid-β40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cerebrospinal fluid; Chemistry; In vivo; Endocrinology; Calcitriol; Blood–brain barrier; Internal medicine; Pharmacology; Medicine; Vitamin D and neurology; Biology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005534585,0.0007286046,0.0007151885,0.0007431843,0.0003687912,0.0008644373,0.00040127,0.0006471577,0.001498108],"category_scores_gemma":[0.0004931018,0.0005073454,0.0006116949,0.0005536969,0.0007998327,0.001116824,0.0001526198,0.001496626,0.0008465303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007479831,"about_ca_system_score_gemma":0.00106486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006257099,"about_ca_topic_score_gemma":0.005051356,"domain_scores_codex":[0.9996738,0.00006012758,0.00001581493,0.00008951476,0.00004628949,0.0001144214],"domain_scores_gemma":[0.9994866,0.0001251339,0.0001315408,0.00007545728,0.00005728106,0.0001239105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03110689,0.001039087,0.001204336,0.00007744478,0.00007620559,0.0002635425,0.0002554256,0.0006122909,0.9560257,0.0003134265,0.000275331,0.008750334],"study_design_scores_gemma":[0.0002405089,0.004591215,0.005705006,0.000007572977,0.0001310581,0.0003049555,0.0001737302,0.002476387,0.9850128,0.0002521901,0.001063337,0.0000413823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991467,0.002494833,0.003113583,0.0001128057,0.0001192443,0.00004687437,0.0007880061,0.0002519928,0.00160562],"genre_scores_gemma":[0.9860277,0.002146895,0.002328797,0.00006823619,0.00005345042,0.00008398672,0.0009232084,0.0001694632,0.008198368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006257099,"threshold_uncertainty_score":0.01244134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122551607786759,"score_gpt":0.2697454494703282,"score_spread":0.2585199333924606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}