{"id":"W3047120020","doi":"10.1016/j.scr.2020.101935","title":"Establishment of variant free-iPSC (UOMi003-A) line from patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Heteroplasmy; Lactic acidosis; Biology; Induced pluripotent stem cell; Encephalopathy; MELAS syndrome; Mitochondrial DNA; Mitochondrial myopathy; Mitochondrial encephalomyopathy; Mitochondrial disease; Mutation; Mitochondrion; Acidosis; Internal medicine; Genetics; Endocrinology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472779,0.0001863723,0.0002713225,0.00007500961,0.0001119074,0.00004990018,0.0002996956,0.0001951619,0.0001482853],"category_scores_gemma":[0.0001061813,0.0001531169,0.0000601851,0.0001969929,0.0002078054,0.000009626935,0.000395606,0.0003121805,0.00001787911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001737978,"about_ca_system_score_gemma":0.0001903212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001899413,"about_ca_topic_score_gemma":0.0001032856,"domain_scores_codex":[0.9977079,0.0004420281,0.0003091158,0.0006484222,0.0005053595,0.0003871546],"domain_scores_gemma":[0.998689,0.0001229772,0.0001081335,0.000526445,0.00026799,0.0002854368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002063541,0.0001365427,0.0007935408,0.00006541077,0.00005232777,0.00006234614,0.0006536733,0.00002721728,0.9877123,0.00004377656,0.004445476,0.003943836],"study_design_scores_gemma":[0.002746668,0.005395238,0.0001414595,0.00003329431,0.00003671334,0.00001841398,0.00150081,0.0001646823,0.9434271,0.00004429548,0.04623156,0.0002598055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889634,0.002807987,0.003216617,0.0007473109,0.0005054923,0.000689713,0.0003418313,0.0000164548,0.002711239],"genre_scores_gemma":[0.9948565,0.0006067759,0.002884195,0.0002113881,0.0005287349,0.00005786198,0.0001382655,0.00003105316,0.0006852024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04428525,"threshold_uncertainty_score":0.6243926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02998884196463011,"score_gpt":0.2669794783946467,"score_spread":0.2369906364300166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}