{"id":"W3047120020","doi":"10.1016/j.scr.2020.101935","title":"Establishment of variant free-iPSC (UOMi003-A) line from patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Heteroplasmy; Lactic acidosis; Biology; Induced pluripotent stem cell; Encephalopathy; MELAS syndrome; Mitochondrial DNA; Mitochondrial myopathy; Mitochondrial encephalomyopathy; Mitochondrial disease; Mutation; Mitochondrion; Acidosis; Internal medicine; Genetics; Endocrinology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570917,0.0002182824,0.000238667,0.0004110981,0.0002994147,0.0003089981,0.0002224386,0.0004129471,0.002639524],"category_scores_gemma":[0.0002338496,0.0001137565,0.0002216603,0.0002636487,0.0001935997,0.0001434196,0.0002857723,0.0005471738,0.0007407904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009166,"about_ca_system_score_gemma":0.000123084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003825274,"about_ca_topic_score_gemma":0.0006264452,"domain_scores_codex":[0.9998707,0.00001180812,0.00002654011,0.00003950574,0.00003547258,0.00001585314],"domain_scores_gemma":[0.9999133,0.00002188271,0.0000123877,0.00002084913,0.000009978074,0.00002147236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001313363,0.00008265325,0.003082634,0.0000530063,0.00001558809,0.003857725,0.0002357954,0.0001310249,0.9825574,0.0006843513,0.0003747798,0.008793755],"study_design_scores_gemma":[0.00006988606,0.000699415,0.04001777,0.00004420473,0.0001035044,0.04294111,0.0002656689,0.002318885,0.8915597,0.000708964,0.02123673,0.00003414834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771086,0.0006912615,0.01500118,0.0001833068,0.0000928964,0.0001949207,0.002552204,0.0002432216,0.003932339],"genre_scores_gemma":[0.9779383,0.0007602521,0.01147649,0.0001361851,0.00003633389,0.0001747748,0.005024407,0.00008622129,0.004367008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002639524,"threshold_uncertainty_score":0.00883013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02998884196463011,"score_gpt":0.2669794783946467,"score_spread":0.2369906364300166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}