{"id":"W3047120178","doi":"10.1038/s42003-020-01153-3","title":"Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fluidigm (Canada); York University; Sanofi (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Sanofi Pasteur; Sanofi","keywords":"Immunogenicity; Pertussis toxin; Bordetella pertussis; Mutant; Chemistry; Pertussis vaccine; Antigen; Biology; Genetics; Biochemistry; Receptor; G protein; Immunization; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057564,0.0002053116,0.0003348102,0.00005867563,0.0005857622,0.00005198508,0.0007106952,0.0003852777,0.0007305912],"category_scores_gemma":[0.0005789825,0.0001784928,0.00005840231,0.000381824,0.0003438735,0.00006657976,0.0009663342,0.0003970274,0.0003560753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002174278,"about_ca_system_score_gemma":0.00006738731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006125757,"about_ca_topic_score_gemma":0.0001455599,"domain_scores_codex":[0.9985165,0.0004025438,0.000393274,0.0003618328,0.0000115952,0.0003142386],"domain_scores_gemma":[0.9985501,0.0002149929,0.00007782805,0.0008639605,0.0001988252,0.0000943012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001343604,0.00006662093,0.004329054,0.000007600608,0.0001337178,2.203569e-7,0.0003576772,0.00001017993,0.9852712,0.005702594,0.001119411,0.002867324],"study_design_scores_gemma":[0.003907692,0.002516087,0.1686338,0.00006942968,0.000503792,0.0003616073,0.0004439106,0.001589594,0.1536518,0.001032435,0.665653,0.001636888],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836209,0.004586548,0.0005240329,0.01014367,0.0003558797,0.0003195404,0.0001279111,0.00009534455,0.0002262024],"genre_scores_gemma":[0.9951959,0.0007183569,0.002454176,0.001117506,0.00005094446,0.00002180248,0.0003250582,0.00001877274,0.00009753592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8316194,"threshold_uncertainty_score":0.7999461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04621486475743707,"score_gpt":0.2845718430720731,"score_spread":0.238356978314636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}