{"id":"W3047174710","doi":"10.1002/1878-0261.12775","title":"Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death","year":2020,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cilostazol; Statin; Pharmacology; Phosphodiesterase; Dipyridamole; Medicine; Apoptosis; Phosphodiesterase inhibitor; Phosphodiesterase 3; Cancer research; Chemistry; Internal medicine; Biochemistry; Enzyme; Aspirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444764,0.0003044681,0.0003802356,0.000385838,0.0001409481,0.0002094319,0.0001298744,0.0001980027,0.001245015],"category_scores_gemma":[0.0001225246,0.00008994518,0.0002898556,0.0002499612,0.0001436303,0.0001140941,0.0001603618,0.0005223496,0.000239103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002784676,"about_ca_system_score_gemma":0.0003531915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008706457,"about_ca_topic_score_gemma":0.003030725,"domain_scores_codex":[0.9998266,0.00003155107,0.00001584483,0.00001678606,0.00004934973,0.00005983523],"domain_scores_gemma":[0.9999322,0.00001663511,0.00001421021,0.000008783828,0.00001103874,0.00001714165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003394183,0.0001453418,0.0003267952,0.00008988926,0.00001666385,0.00007059952,0.00001432958,0.0001428608,0.9927544,0.00009269473,0.0001205325,0.005886414],"study_design_scores_gemma":[0.00006101769,0.001844139,0.007949235,0.000009124796,0.00003406952,0.0002237128,0.00002313244,0.0009081524,0.9862708,0.00004162149,0.002630498,0.000004555161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886876,0.005541878,0.001722853,0.0002371218,0.00008160488,0.00009563396,0.0003637166,0.00008371746,0.00318586],"genre_scores_gemma":[0.9925132,0.003224104,0.001717405,0.0001343229,0.00002236826,0.00005130057,0.0004216075,0.000005495023,0.001910234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245015,"threshold_uncertainty_score":0.004164994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479412783595812,"score_gpt":0.2886751896524001,"score_spread":0.263881061816442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}