{"id":"W3047190724","doi":"10.1158/1538-7445.pedca19-ia31","title":"Abstract IA31: Stalled developmental programs at the root of K27M mutant gliomas and other pediatric brain tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Progenitor cell; OLIG2; PRC2; Lineage (genetic); Progenitor; Neuroscience; Wnt signaling pathway; Neural stem cell; Cellular differentiation; Epigenetics; Cancer research; Stem cell; Cell biology; Genetics; Central nervous system; EZH2; Oligodendrocyte; Myelin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004155519,0.0001924011,0.0002305111,0.0004599954,0.0001788809,0.0002684463,0.0001155157,0.0001566279,0.001643],"category_scores_gemma":[0.00008309539,0.0001078729,0.0001667698,0.000336699,0.0001306185,0.00009365244,0.0002084235,0.000249593,0.0005828094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728618,"about_ca_system_score_gemma":0.0001771512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469831,"about_ca_topic_score_gemma":0.002429034,"domain_scores_codex":[0.9999341,0.000002585003,0.000003682168,0.00002284958,0.00001813075,0.00001861786],"domain_scores_gemma":[0.9998981,0.00001205361,0.00003382948,0.00001482131,0.00001115285,0.00003002507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106465,0.000007936738,0.005637679,0.00002561239,0.000008880803,0.0002038716,0.00003474049,0.0002532917,0.9910859,0.00009322116,0.0001562287,0.002386096],"study_design_scores_gemma":[0.00000783851,0.0001562837,0.3345954,0.00001038352,0.00003198684,0.002454324,0.000184857,0.003683636,0.6516771,0.0002718684,0.006911791,0.00001439014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923625,0.0002199541,0.002108761,0.00001919768,0.000003753757,0.00001050903,0.004200076,0.000196156,0.0008789877],"genre_scores_gemma":[0.9894847,0.0002095536,0.002335209,0.00002211214,0.000002237538,0.0000253906,0.005208641,0.00008743236,0.002624789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643,"threshold_uncertainty_score":0.005496383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06355479748055734,"score_gpt":0.3565387594744608,"score_spread":0.2929839619939034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}