{"id":"W3047205060","doi":"10.1158/1538-7445.pedca19-b01","title":"Abstract B01: Alternative splicing as a therapeutic vulnerability in pediatric rhabdomyosarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RNA splicing; Alternative splicing; Pediatric cancer; Biology; splice; Rhabdomyosarcoma; Cancer research; Splice site mutation; Carcinogenesis; Cancer; Gene isoform; Computational biology; Genetics; Medicine; Gene; RNA; Sarcoma; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003606695,0.0001643023,0.0002183986,0.0002149363,0.0001518722,0.0002410491,0.0001494238,0.0003205298,0.001346852],"category_scores_gemma":[0.0002358622,0.00006081849,0.0001996929,0.0002017726,0.0003113743,0.0001361139,0.0001494162,0.0004984152,0.0003215834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661585,"about_ca_system_score_gemma":0.0002557074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002318736,"about_ca_topic_score_gemma":0.0002322562,"domain_scores_codex":[0.9998845,0.00002566588,0.00001123458,0.00002280356,0.00003170674,0.00002416704],"domain_scores_gemma":[0.9998292,0.00004477964,0.00006424746,0.00001136848,0.00001974959,0.00003058661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0015302,0.0004494724,0.01886393,0.0002569279,0.00003882258,0.003304708,0.0001041197,0.001187461,0.8926015,0.001722103,0.001275728,0.07866489],"study_design_scores_gemma":[0.0002702531,0.01086623,0.08003297,0.0000970028,0.0001833499,0.02668002,0.0002977875,0.003986983,0.8473398,0.001933045,0.02828111,0.00003151401],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9864041,0.004036836,0.003998735,0.0005309155,0.00005698272,0.00007227794,0.0001936334,0.0001016894,0.004604741],"genre_scores_gemma":[0.9933726,0.002224413,0.002891622,0.0002306596,0.00003156694,0.00004215873,0.0002629617,0.000020768,0.0009233337],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001346852,"threshold_uncertainty_score":0.004505694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1089355518151441,"score_gpt":0.4260212869624933,"score_spread":0.3170857351473491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}