{"id":"W3047209647","doi":"10.1158/1538-7445.pedca19-a08","title":"Abstract A08: Development of FGFR4-specific chimeric antibody receptor (CAR) T cell and bispecific T cell engager (BiTE) for rhabdomyosarcoma (RMS) immunotherapy","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Monoclonal antibody; In vivo; Immunotherapy; In vitro; Alveolar rhabdomyosarcoma; Antibody; T cell; Medicine; Molecular biology; Biology; Immunology; Rhabdomyosarcoma; Immune system; Pathology; Biochemistry; Sarcoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002509211,0.0005290018,0.0002580049,0.0003646125,0.0001439073,0.0003553568,0.0004492827,0.000628559,0.002434141],"category_scores_gemma":[0.0001237715,0.0001534301,0.0004228709,0.0002006758,0.0001444209,0.0002917995,0.0003672171,0.000620052,0.0009940758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003363555,"about_ca_system_score_gemma":0.0002833823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002860937,"about_ca_topic_score_gemma":0.0003212267,"domain_scores_codex":[0.9997923,0.00002474579,0.00001650451,0.00004224932,0.00007554705,0.00004876963],"domain_scores_gemma":[0.9999325,0.000005457053,0.00001404952,0.000006284936,0.00001752724,0.00002416566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001477203,0.000236667,0.0005241122,0.00009640509,0.0000184557,0.0001228653,0.00003192352,0.0006275577,0.9859449,0.0003802492,0.0005202279,0.0113488],"study_design_scores_gemma":[0.00009813741,0.002746276,0.001735294,0.00001064239,0.00004876405,0.0006742995,0.00002381121,0.003009876,0.9808447,0.0001068864,0.0106888,0.00001247537],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9637956,0.002284071,0.0240711,0.000332902,0.0001025247,0.0005819535,0.0009291652,0.0004774126,0.007425362],"genre_scores_gemma":[0.9670097,0.001243039,0.02073109,0.0001727436,0.00002458746,0.0002797623,0.002124564,0.00004339136,0.008371125],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002434141,"threshold_uncertainty_score":0.008143008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1123709370390115,"score_gpt":0.3963435076616698,"score_spread":0.2839725706226583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}