{"id":"W3047235899","doi":"10.1158/1538-7445.pedca19-b46","title":"Abstract B46: CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb Repressive complex 2 via a H3K27M-like mechanism","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PRC2; Histone H3; Histone; Fusion protein; Epigenetics; DNA methylation; Methylation; EZH2; Fusion gene; Methionine; Biology; Gene; Chemistry; Cell biology; Molecular biology; Genetics; Gene expression; Amino acid; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007732353,0.0004866799,0.0001833113,0.0002295866,0.0002320771,0.0002361624,0.0003574632,0.000314575,0.004450023],"category_scores_gemma":[0.00006832005,0.0001149998,0.00020821,0.0002247183,0.0002779186,0.0001045277,0.0002344606,0.0005108404,0.001945631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000368348,"about_ca_system_score_gemma":0.0002053136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008161398,"about_ca_topic_score_gemma":0.000865993,"domain_scores_codex":[0.9998999,0.0000121031,0.000007710486,0.0000264268,0.00003386614,0.00002002643],"domain_scores_gemma":[0.9999297,0.000005452819,0.00001978967,0.00000904954,0.000004590284,0.00003143065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242981,0.00002979339,0.0001206475,0.00003227923,0.000003570271,0.00008631328,0.000006482058,0.00007160162,0.9976546,0.0003037193,0.0003018698,0.001264918],"study_design_scores_gemma":[0.000060234,0.0001919448,0.003257757,0.000008787785,0.00001098519,0.0005182753,0.00001276952,0.001184013,0.9773031,0.00006736958,0.01737787,0.000006929722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586833,0.006683333,0.01493364,0.0007849607,0.0005451709,0.0001995241,0.003892029,0.001581396,0.01269669],"genre_scores_gemma":[0.9583756,0.001351827,0.007255063,0.0002157254,0.00006223547,0.0001692802,0.005074724,0.0001977038,0.02729778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004450023,"threshold_uncertainty_score":0.0148868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.239808688946201,"score_gpt":0.4056006710918198,"score_spread":0.1657919821456188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}