{"id":"W3047237087","doi":"10.1182/blood.v130.suppl_1.2516.2516","title":"Loss of Ahi-1 Impairs the Self-Renewal Activity of Normal and BCR-ABL+ Stem Cells in Vitro and in Vivo","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Stem cell; Biology; Haematopoiesis; Cancer research; Progenitor cell; Embryonic stem cell; Chronic myelogenous leukemia; ABL; Myeloid; Cell biology; Imatinib mesylate; Leukemia; Tyrosine kinase; Myeloid leukemia; Immunology; Molecular biology; Imatinib; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001933864,0.0003345388,0.0001994208,0.0003658245,0.0001363085,0.0002778677,0.0002568022,0.0003367981,0.002059116],"category_scores_gemma":[0.0000852806,0.0001514914,0.000211257,0.0001553992,0.0002308762,0.0001778145,0.0001788277,0.0007450961,0.0006101729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487786,"about_ca_system_score_gemma":0.0001569072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381128,"about_ca_topic_score_gemma":0.0003246175,"domain_scores_codex":[0.999778,0.00003280605,0.00003063371,0.00003782123,0.00006929631,0.00005159251],"domain_scores_gemma":[0.9997849,0.00004100503,0.00005805733,0.00002354653,0.000009681826,0.00008287494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006659522,0.00004932803,0.00009789433,0.00001176442,0.000002877814,0.00002488932,0.000006917213,0.00005465585,0.9990343,0.0001015274,0.0000261869,0.0005230809],"study_design_scores_gemma":[0.00001638348,0.0004080952,0.003123904,0.000003888371,0.00001093909,0.0001760523,0.00002277911,0.0009521138,0.9935932,0.00004466574,0.001645038,0.000003045406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956906,0.001107242,0.001309576,0.00007349698,0.00003365473,0.00002694621,0.0006777148,0.0000975693,0.0009830854],"genre_scores_gemma":[0.9943066,0.00040146,0.000604787,0.0000365988,0.000007066275,0.00003853053,0.0008988337,0.00002041709,0.003685547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059116,"threshold_uncertainty_score":0.00688839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017760632374411,"score_gpt":0.2411732225410902,"score_spread":0.2309956162173461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}