{"id":"W3047241006","doi":"10.1093/noajnl/vdaa073.058","title":"71. MGMT PROMOTER METHYLATION IS A PROGNOSTIC BIOMARKER IN EGFR MUTANT LUNG ADENOCARCINOMA WITH BRAIN METASTASES","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Princess Margaret Cancer Centre","funders":"","keywords":"Methylation; Oncology; DNA methylation; Lung cancer; Adenocarcinoma; Biomarker; Medicine; Internal medicine; Proportional hazards model; CpG site; Cancer; Stage (stratigraphy); Cancer research; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009512708,0.0002190777,0.0004135804,0.000131054,0.00007460781,0.00001636364,0.00007583295,0.00007851976,0.0001723884],"category_scores_gemma":[0.0003179334,0.0001569437,0.00005993107,0.0004095343,0.0001251833,0.0002963271,0.00003138705,0.0002035277,0.00002175256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479084,"about_ca_system_score_gemma":0.0003074226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002335885,"about_ca_topic_score_gemma":0.0001215574,"domain_scores_codex":[0.9985174,0.0001644206,0.0003057047,0.0005110654,0.0002033338,0.000298056],"domain_scores_gemma":[0.9990251,0.000414825,0.0001443721,0.0001668192,0.00008689587,0.0001619808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002919371,0.001069309,0.7961693,0.0005265198,0.0006701172,0.004002301,0.00748162,0.00014978,0.1074797,0.0001925486,0.003059299,0.07628003],"study_design_scores_gemma":[0.02303146,0.01474115,0.6439592,0.0003854492,0.002975067,0.001055488,0.00181389,0.00554066,0.0446473,0.0004799848,0.2604636,0.0009068436],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9168044,0.006460128,0.001224931,0.07009256,0.0002249834,0.002680802,0.00008094542,0.0001590685,0.002272149],"genre_scores_gemma":[0.9884442,0.0001053338,0.002716939,0.008231748,0.00007046473,0.000283698,0.00006197007,0.00003294761,0.00005269614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2574043,"threshold_uncertainty_score":0.639998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438382448437263,"score_gpt":0.3437997888631176,"score_spread":0.3194159643787449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}