{"id":"W3047241006","doi":"10.1093/noajnl/vdaa073.058","title":"71. MGMT PROMOTER METHYLATION IS A PROGNOSTIC BIOMARKER IN EGFR MUTANT LUNG ADENOCARCINOMA WITH BRAIN METASTASES","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Princess Margaret Cancer Centre","funders":"","keywords":"Methylation; Oncology; DNA methylation; Lung cancer; Adenocarcinoma; Biomarker; Medicine; Internal medicine; Proportional hazards model; CpG site; Cancer; Stage (stratigraphy); Cancer research; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617939,0.0001795725,0.0001865058,0.0003616075,0.0001517392,0.0003302173,0.0001482398,0.000212591,0.001530747],"category_scores_gemma":[0.0008033552,0.0001157431,0.0001787516,0.0003609168,0.000111894,0.0001249621,0.0002272758,0.0002484823,0.0002796748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693037,"about_ca_system_score_gemma":0.0001221885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002007594,"about_ca_topic_score_gemma":0.002844933,"domain_scores_codex":[0.999871,0.00002816956,0.000009354901,0.00003220312,0.00003540432,0.00002391474],"domain_scores_gemma":[0.999714,0.00006580249,0.0001039592,0.00001932331,0.00003943481,0.00005747271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006139184,0.0000238025,0.9808401,0.00001593264,0.00004941752,0.0000997794,0.00002200387,0.0001603105,0.01163783,0.00001733185,0.0001288533,0.006390756],"study_design_scores_gemma":[0.000006456511,0.0001556503,0.9959579,0.000003060381,0.00003940101,0.0003303991,0.00003319525,0.0009633307,0.002214646,0.00004436778,0.0002489793,0.000002582078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990128,0.0003208416,0.0001916346,0.00002541276,0.000003619998,0.000003505873,0.0001774111,0.000008332209,0.0002564371],"genre_scores_gemma":[0.9995652,0.00004569988,0.00008359104,0.000005304457,0.000003012001,0.000002396666,0.0001294797,0.000001142772,0.000164184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002007594,"threshold_uncertainty_score":0.005120814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438382448437263,"score_gpt":0.3437997888631176,"score_spread":0.3194159643787449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}