{"id":"W3047245360","doi":"10.1158/1538-7445.pedca19-b24","title":"Abstract B24: Dysregulated Transcription Drives Splicing Defect in Ewing Sarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RNA splicing; Biology; RNA polymerase II; Alternative splicing; Phenotype; Pediatric cancer; Transcription (linguistics); Genetics; Cell biology; Cancer; RNA; Gene; Gene isoform; Gene expression; Promoter","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327743,0.0004372279,0.0002588567,0.0005781231,0.0002047141,0.0002619989,0.0003178195,0.0006468919,0.004391548],"category_scores_gemma":[0.0002328613,0.0001651955,0.000324254,0.0002198301,0.0003721584,0.0001131445,0.0003021925,0.0006199574,0.002237239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913267,"about_ca_system_score_gemma":0.0001485621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002865275,"about_ca_topic_score_gemma":0.0002509168,"domain_scores_codex":[0.99979,0.00003018754,0.00003746206,0.00006035507,0.0000619199,0.00002003002],"domain_scores_gemma":[0.9997144,0.00005672791,0.0000883383,0.00003225017,0.00002400783,0.00008425506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003547491,0.00002544875,0.0003357291,0.00002147572,0.000004899295,0.002192742,0.00001522563,0.00006220984,0.9959496,0.0002149969,0.0001380912,0.001004121],"study_design_scores_gemma":[0.00004381561,0.0005191255,0.01519103,0.00002872539,0.00002939824,0.02561789,0.0001010423,0.002412997,0.9421138,0.0009602944,0.01295455,0.00002723268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863371,0.001168011,0.006230706,0.0004340646,0.0002319012,0.00006113615,0.001877426,0.0005854499,0.003074265],"genre_scores_gemma":[0.9914278,0.0005320873,0.002059557,0.0001446602,0.00003956653,0.00003211391,0.001051827,0.0001495249,0.004562725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004391548,"threshold_uncertainty_score":0.01469117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08672364914761188,"score_gpt":0.3787164289620253,"score_spread":0.2919927798144134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}