{"id":"W3047263629","doi":"10.1158/1538-7445.pedca19-b50","title":"Abstract B50: Targeting EWS/FLI fusion oncoprotein stability/degradation in Ewing sarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transcription factor; Fusion protein; Cancer research; Carcinogenesis; Biology; Druggability; Protein degradation; Computational biology; Cancer; Genetics; Cell biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152519,0.0003154541,0.0003680363,0.0003765235,0.0001992656,0.000296834,0.0002773265,0.0005803442,0.002616443],"category_scores_gemma":[0.0001578528,0.0001437874,0.0003553275,0.0001825679,0.0001991298,0.0002317065,0.0002889272,0.0006112307,0.0009857297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004847936,"about_ca_system_score_gemma":0.0002499026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008004947,"about_ca_topic_score_gemma":0.0008606231,"domain_scores_codex":[0.9997888,0.00001532474,0.00002103945,0.00004870755,0.00008122784,0.00004478057],"domain_scores_gemma":[0.999911,0.00001332445,0.00002165796,0.000009072408,0.00001477301,0.00003014559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004283961,0.00003201045,0.0001117963,0.00004291554,0.000003697394,0.00005137372,0.000005336122,0.00007380493,0.9977071,0.00009153553,0.0001359477,0.001701633],"study_design_scores_gemma":[0.00001217359,0.0002043211,0.001180174,0.000006104394,0.00001389284,0.0003168595,0.000009686434,0.001122066,0.9928356,0.00004407168,0.004250102,0.000004962686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602695,0.004757991,0.02220091,0.0004681867,0.0001425116,0.0003192438,0.002796617,0.001255728,0.007789354],"genre_scores_gemma":[0.9771947,0.001143043,0.01129849,0.0002505151,0.00001143825,0.0001033199,0.002397991,0.0000914073,0.007509085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616443,"threshold_uncertainty_score":0.008752823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09127641192772956,"score_gpt":0.3712006484416381,"score_spread":0.2799242365139085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}