{"id":"W3047268629","doi":"10.1093/nar/gkaa646","title":"RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"EIF4G; EIF4E; Biology; eIF4A; Initiation factor; Eukaryotic translation; Eukaryotic initiation factor; Cell biology; Internal ribosome entry site; Translation (biology); RNA; Ribosome; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007364574,0.0004961028,0.0004179506,0.0003324087,0.0003064621,0.0003266668,0.0005098369,0.0005838483,0.001573868],"category_scores_gemma":[0.0005097319,0.000398026,0.0003259196,0.0003097148,0.0002834682,0.0002945921,0.0003416071,0.0007625544,0.0004051819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004381406,"about_ca_system_score_gemma":0.00017799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667595,"about_ca_topic_score_gemma":0.0007336945,"domain_scores_codex":[0.9988464,0.000355007,0.0001301502,0.0003168677,0.0002493357,0.0001022254],"domain_scores_gemma":[0.9996063,0.0001097085,0.00009113782,0.00005830334,0.00005202373,0.00008249303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005665838,0.0000527486,0.0001458697,0.00002651152,0.000006665984,0.00001072289,0.00001185197,0.0001094135,0.9988528,0.00006293679,0.00001560418,0.0006481107],"study_design_scores_gemma":[0.00001029353,0.0001630522,0.0006451424,0.000001935529,0.00001101249,0.00003211408,0.000009444918,0.002094758,0.9965749,0.00002526562,0.0004269796,0.000004921952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803982,0.000388423,0.01806941,0.00007669502,0.0000261457,0.00009558732,0.0001567867,0.00009881062,0.0006899544],"genre_scores_gemma":[0.9630677,0.0002325465,0.03308224,0.00007253479,0.000007777243,0.0001697644,0.0008003821,0.00004964932,0.002517365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573868,"threshold_uncertainty_score":0.005265117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09803317904971151,"score_gpt":0.3086166476821937,"score_spread":0.2105834686324821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}