{"id":"W3047301471","doi":"10.1158/1538-7445.pedca19-a34","title":"Abstract A34: Hypoxia signaling pathway is frequently involved in pediatric osteosarcoma microenvironment, as diagnostic and prognostic biomarkers, but also as new therapeutic targets","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hypoxia (environmental); Osteosarcoma; PI3K/AKT/mTOR pathway; Cancer research; Medicine; Autophagy; Signal transduction; Tumor microenvironment; Cancer; Stromal cell; Biology; Internal medicine; Apoptosis; Chemistry; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884791,0.0002767436,0.0002725628,0.0004387868,0.0001962246,0.0003583195,0.0001024437,0.0002333022,0.002023843],"category_scores_gemma":[0.0001715992,0.0001180249,0.0002370754,0.0004627198,0.0001809033,0.0002028505,0.0001689916,0.0003263337,0.0002924119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347017,"about_ca_system_score_gemma":0.0002423507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005574373,"about_ca_topic_score_gemma":0.0005499143,"domain_scores_codex":[0.9998465,0.00002685343,0.00001550341,0.00004118305,0.00003912591,0.00003087423],"domain_scores_gemma":[0.9998393,0.00002041924,0.00007861295,0.000007499494,0.00002758309,0.00002661057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001350251,0.0001047842,0.09887415,0.0005069628,0.00008772386,0.0008553868,0.00007916246,0.0003300527,0.8585519,0.0003587733,0.001060908,0.03783993],"study_design_scores_gemma":[0.00004971496,0.001306923,0.6054314,0.00007845143,0.0002575221,0.008605451,0.0002535689,0.001766542,0.3643557,0.0004542075,0.01742176,0.0000187661],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752952,0.01874031,0.002595262,0.000329516,0.00004071967,0.00004519205,0.001269729,0.00008028596,0.001603719],"genre_scores_gemma":[0.9922708,0.003821386,0.001516571,0.00009420719,0.0000328797,0.0000320927,0.001191906,0.00001281622,0.001027277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023843,"threshold_uncertainty_score":0.006770432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04013945347838324,"score_gpt":0.3088842102212721,"score_spread":0.2687447567428889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}