{"id":"W3047302402","doi":"10.1158/1538-7445.pedca19-a50","title":"Abstract A50: Targeted therapies for children and young adults with cancer: Single-patient use (SPU) experience at three large pediatric cancer programs","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cancer; Pediatric cancer; Clinical trial; Single Center; Malignancy; Pediatric oncology; Expanded access; Internal medicine; Oncology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010718,0.0002192424,0.0003218766,0.00005415881,0.0004900981,0.0001081627,0.0001492338,0.00007563665,0.0004728262],"category_scores_gemma":[0.0001599293,0.0001501567,0.00005461999,0.0004993193,0.0002356383,0.0002813603,0.0001842081,0.0004671879,0.000004198318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670912,"about_ca_system_score_gemma":0.0002050037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006026193,"about_ca_topic_score_gemma":0.005696627,"domain_scores_codex":[0.9975825,0.0000480604,0.0002283196,0.0005935473,0.0007280178,0.0008195407],"domain_scores_gemma":[0.9986145,0.0002131308,0.0001039033,0.0001759083,0.0004436366,0.0004488424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007510887,0.000261592,0.8964136,0.0004993749,0.0003175969,0.00002546835,0.01162276,0.000005747399,0.003016744,0.000008572293,0.003750694,0.07656695],"study_design_scores_gemma":[0.008781984,0.003486311,0.8584532,0.0004957987,0.0003062049,0.00001425507,0.0026674,0.0003714636,0.009965319,0.00001185504,0.1147889,0.0006573179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9377792,0.05302981,0.000009713697,0.006487504,0.0001171635,0.002188719,0.0002813425,0.00005516095,0.00005133408],"genre_scores_gemma":[0.9710091,0.02528419,0.0001241683,0.0006291404,0.0007138345,0.002089747,0.00003220732,0.00004514036,0.00007245762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1110382,"threshold_uncertainty_score":0.9109842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1629694053006241,"score_gpt":0.4323104505791051,"score_spread":0.2693410452784809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}