{"id":"W3047307029","doi":"10.1053/j.gastro.2020.07.048","title":"A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"Seres Therapeutics","keywords":"Ulcerative colitis; Microbiome; Colitis; Gastroenterology; Phase (matter); Medicine; Microbiology; Internal medicine; Chemistry; Bioinformatics; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001180656,0.0009474273,0.001390387,0.0002626412,0.0004036298,0.0009943779,0.0005105376,0.001505202,0.004896441],"category_scores_gemma":[0.001331381,0.0003589188,0.00107829,0.0002092742,0.0007223857,0.0006041393,0.000224042,0.003108083,0.001002545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342255,"about_ca_system_score_gemma":0.00105808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006291925,"about_ca_topic_score_gemma":0.001407109,"domain_scores_codex":[0.9996479,0.0001841467,0.00001360738,0.00006420506,0.0000383182,0.00005181032],"domain_scores_gemma":[0.9992767,0.0002073033,0.0001078604,0.00006190192,0.0000614086,0.0002848705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7882366,0.03843737,0.003158441,0.00160359,0.001825731,0.0003258284,0.0002932334,0.002051333,0.04145331,0.0007916261,0.00792429,0.1138987],"study_design_scores_gemma":[0.5921715,0.3868959,0.00776948,0.0001115767,0.0006880923,0.0004579423,0.00008513828,0.001366288,0.004001519,0.0006856418,0.005731517,0.00003539148],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826369,0.004585298,0.002171837,0.001134124,0.000342901,0.002282642,0.001683997,0.0002729898,0.004889266],"genre_scores_gemma":[0.9862738,0.002713377,0.001797774,0.002163655,0.0002197734,0.001288312,0.001703528,0.00006362495,0.003776053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004896441,"threshold_uncertainty_score":0.01638019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05283503503327722,"score_gpt":0.3435181549618764,"score_spread":0.2906831199285992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}