{"id":"W3047307029","doi":"10.1053/j.gastro.2020.07.048","title":"A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"Seres Therapeutics","keywords":"Ulcerative colitis; Microbiome; Colitis; Gastroenterology; Phase (matter); Medicine; Microbiology; Internal medicine; Chemistry; Bioinformatics; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001754479,0.0002944737,0.0008342902,0.0002049088,0.0001024358,0.00001493996,0.0002029018,0.0001023657,0.0001509619],"category_scores_gemma":[0.00007542361,0.0002713559,0.0001939036,0.0003027096,0.0001149358,0.00003879266,0.00009685923,0.0002887264,0.00001808702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475043,"about_ca_system_score_gemma":0.0001811362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008174233,"about_ca_topic_score_gemma":0.0002254554,"domain_scores_codex":[0.9977015,0.0001999525,0.000538353,0.0006180205,0.0002625725,0.0006795661],"domain_scores_gemma":[0.9986065,0.0001133692,0.0001343329,0.0003346091,0.0003987363,0.0004124206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.5209797,0.02118241,0.003982175,0.0003503014,0.001618431,0.0001952447,0.009324734,0.0004769595,0.4321688,0.00002975539,0.002970031,0.006721423],"study_design_scores_gemma":[0.1998164,0.2231698,0.0209532,0.0001422363,0.0008078038,0.00008194297,0.007725538,0.01171219,0.5306051,0.00001901403,0.004462212,0.0005045634],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810462,0.00001617663,0.004457304,0.01003736,0.00006963155,0.003418905,0.0008576488,0.00004547254,0.00005132155],"genre_scores_gemma":[0.9942314,0.000006748473,0.0004255706,0.004611576,0.0001625326,0.0002966346,0.0001586665,0.00004643685,0.00006042333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3211633,"threshold_uncertainty_score":0.9999738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05283503503327722,"score_gpt":0.3435181549618764,"score_spread":0.2906831199285992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}