{"id":"W3047346934","doi":"10.1371/journal.ppat.1008696","title":"Selective Upregulation of CTLA-4 on CD8+ T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Institute of Infection and Immunity; Canadian Institutes of Health Research; University of Alberta","keywords":"Cytotoxic T cell; CD8; Downregulation and upregulation; Human leukocyte antigen; HLA-B; Immunology; Biology; Epitope; Phenotype; Virology; Immune system; Antigen; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008684057,0.0001710563,0.0001502291,0.00008604347,0.0001055995,0.0001931071,0.00008642701,0.0001782247,0.001178356],"category_scores_gemma":[0.00007344538,0.00009912588,0.0001479104,0.00007105571,0.000132186,0.0001168593,0.0001702655,0.0006996832,0.0002500227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008715009,"about_ca_system_score_gemma":0.00008229319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001541367,"about_ca_topic_score_gemma":0.0001907153,"domain_scores_codex":[0.9998876,0.00001798158,0.00001008866,0.00001862328,0.00002038365,0.00004532725],"domain_scores_gemma":[0.9999532,0.000008703544,0.000007485427,0.000006250528,0.000004191203,0.00002016334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001142656,0.00003260908,0.0002533013,0.00001994254,0.000002003505,0.00004755193,0.00001297614,0.00003265856,0.9985967,0.00003701653,0.00002021803,0.0008306871],"study_design_scores_gemma":[0.00003596709,0.001274387,0.02787542,0.00001474893,0.00002789627,0.0009591013,0.0001218709,0.001375763,0.9666635,0.0001289228,0.001513993,0.000008451888],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987959,0.00031136,0.0003685326,0.00002314918,0.000007990567,0.000005132725,0.0000455484,0.00002197271,0.0004204614],"genre_scores_gemma":[0.9985863,0.0001568283,0.0002995685,0.00003253872,0.000004785677,0.00001152128,0.00009145408,0.000004293274,0.0008127275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178356,"threshold_uncertainty_score":0.003942013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02900306669830923,"score_gpt":0.2285844012203018,"score_spread":0.1995813345219925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}