{"id":"W3047400254","doi":"10.1002/jlb.3mr0720-513r","title":"NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma","year":2020,"lang":"en","type":"review","venue":"Journal of Leukocyte Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Inflammasome; Pyroptosis; Pyrin domain; Priming (agriculture); Nod; Biology; Cell biology; AIM2; Caspase 1; Neuroscience; Immunology; Inflammation; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000609122,0.000566866,0.002093697,0.0004572526,0.0000516211,0.00003697297,0.000833496,0.001002002,0.00002105991],"category_scores_gemma":[0.0003126354,0.0004585166,0.0008405383,0.000270393,0.000142404,0.00001928602,0.0002580812,0.0008580671,0.00002666894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142786,"about_ca_system_score_gemma":0.00139991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001026082,"about_ca_topic_score_gemma":0.00003755894,"domain_scores_codex":[0.9964344,0.0006638327,0.001755891,0.0004918709,0.0001435802,0.0005104181],"domain_scores_gemma":[0.9976406,0.00005420718,0.001482796,0.0004827856,0.0001546746,0.0001849813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005592125,0.000208495,0.0002575581,0.002319827,0.000749309,0.0004521695,0.0003252343,0.000007906193,0.01557432,0.00008254765,0.0005684209,0.978895],"study_design_scores_gemma":[0.00106932,0.001575065,0.00003159164,0.0009455485,0.0001806549,0.0006474843,0.0000896312,0.00000248771,0.0008567488,0.00004315544,0.9940857,0.0004726377],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01803664,0.9805773,0.00005522203,0.00006071767,0.0005650151,0.0003613856,0.00001370708,0.000007839354,0.0003221383],"genre_scores_gemma":[0.003612013,0.9944546,0.0002583741,0.0002090068,0.001051918,0.00002322824,0.0002316521,0.00007713888,0.00008206972],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9935173,"threshold_uncertainty_score":0.9997867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04398893502784011,"score_gpt":0.3402902574639795,"score_spread":0.2963013224361393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}