{"id":"W3047400570","doi":"10.1126/science.abb3231","title":"A short de novo synthesis of nucleoside analogs","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft","keywords":"Nucleoside; Enantioselective synthesis; Nucleoside analogue; Chemistry; Combinatorial chemistry; Nucleic acid; Aldol reaction; Stereochemistry; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019086,0.0000822535,0.0001412251,0.00002068066,0.00007829697,0.00002677623,0.0005270958,0.00004402245,0.0005675658],"category_scores_gemma":[0.0009383784,0.00007943936,0.00006502493,0.0004359984,0.0004508729,0.00009634714,0.00009025101,0.00007807369,0.00001442251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000423015,"about_ca_system_score_gemma":0.0001433963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008952798,"about_ca_topic_score_gemma":0.000001190618,"domain_scores_codex":[0.9990444,0.000004404372,0.0001542372,0.0002781277,0.0002759286,0.0002429014],"domain_scores_gemma":[0.9993649,0.0001058855,0.00003722253,0.0002492117,0.00005084397,0.0001918966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000837477,0.00001577478,0.003924333,0.00005867462,0.000004557118,0.00001195802,0.0002149298,0.00001421538,0.9918112,0.00003580497,0.0000290138,0.003871172],"study_design_scores_gemma":[0.00002514902,0.000003005311,0.0008960392,0.0000272151,0.00001394324,0.00000904059,0.0002438349,0.0007194507,0.9974756,0.00004639423,0.0004487871,0.00009158396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495983,0.00002794601,0.00003146133,0.0004111707,0.0000117137,0.00001152805,0.00001615004,0.00004028212,0.04985145],"genre_scores_gemma":[0.9994119,0.000008804305,0.0003487623,0.0001040762,0.00005328715,0.00000480758,4.089695e-7,0.000006299383,0.00006164136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04981361,"threshold_uncertainty_score":0.6214448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185144122345999,"score_gpt":0.2416643404922808,"score_spread":0.2198128992688208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}