{"id":"W3047412501","doi":"10.1158/1538-7445.pedca19-b45","title":"Abstract B45: Therapeutic potential of splicing in RMS: SRSF2 binding modulation controls MDM2 alternative splicing","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Minigene; RNA splicing; Alternative splicing; Splicing factor; Biology; Exon; Exonic splicing enhancer; Genetics; Mdm2; Cell biology; Cancer research; Gene; RNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383522,0.0002351919,0.0002541845,0.0001485473,0.0001238004,0.000231589,0.0001430074,0.0002620521,0.002982954],"category_scores_gemma":[0.00009802506,0.00007112147,0.0002198234,0.0001156733,0.0001596534,0.0001184139,0.0001054084,0.0004672084,0.0006491084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000121106,"about_ca_system_score_gemma":0.0001424031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003234978,"about_ca_topic_score_gemma":0.000414356,"domain_scores_codex":[0.999861,0.00002399908,0.00001377694,0.0000293251,0.00004077954,0.00003112182],"domain_scores_gemma":[0.9999509,0.000008388524,0.00001307254,0.000006280331,0.000006381251,0.0000148847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432802,0.00003484545,0.00009551211,0.00003138111,0.00000455694,0.00002729115,0.000007321389,0.00005005213,0.997154,0.00009093573,0.00008330785,0.002277537],"study_design_scores_gemma":[0.00004462101,0.0008257565,0.002094414,0.000006125365,0.00002829794,0.0001890585,0.0000188842,0.0006018691,0.9918306,0.0000605172,0.004295191,0.00000469016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889345,0.00293717,0.003980336,0.0002536962,0.0001188361,0.00005852434,0.0004526039,0.0001861475,0.003078245],"genre_scores_gemma":[0.9955332,0.0006832108,0.00154827,0.00007127378,0.00002101098,0.00003696391,0.0003219666,0.00002514297,0.001758966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002982954,"threshold_uncertainty_score":0.00997895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0691222251706888,"score_gpt":0.3936719226216246,"score_spread":0.3245496974509358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}