{"id":"W3047418653","doi":"10.1002/hep.31488","title":"A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Primary sclerosing cholangitis; Fibrosis; Signature (topology); Transcriptome; Medicine; Disease; Internal medicine; Gene signature; Pathology; Biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006309856,0.0001416216,0.0004029008,0.00009943455,0.0000447402,0.00001057966,0.0001160297,0.000110701,0.0001769985],"category_scores_gemma":[0.00006065232,0.0001284563,0.0001498182,0.000198383,0.0001251218,0.0001317618,0.00006130237,0.0002708353,0.00001068567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007444379,"about_ca_system_score_gemma":0.0001891149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008195578,"about_ca_topic_score_gemma":0.00001197923,"domain_scores_codex":[0.998864,0.0001167567,0.000296452,0.0002599194,0.0002224139,0.000240436],"domain_scores_gemma":[0.9993782,0.00003644073,0.00009150561,0.0002015518,0.00004987968,0.0002424394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001320231,0.0002706673,0.9099303,0.001031175,0.00004884995,0.0001843933,0.001303552,0.000003724826,0.08425868,0.00003016266,0.0005468136,0.001071455],"study_design_scores_gemma":[0.002709917,0.0003350804,0.9866081,0.0006279386,0.0002050476,0.00001057038,0.0002558808,0.001363553,0.007459678,0.00006536614,0.0002053261,0.000153525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952859,0.002227532,0.00005044142,0.001634988,0.0001164217,0.0004371512,0.000050448,0.00004721164,0.0001498878],"genre_scores_gemma":[0.9985211,0.0002621614,0.0001372075,0.0009055436,0.00003253637,0.00001823081,0.00008422104,0.0000178361,0.00002108824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07679901,"threshold_uncertainty_score":0.5238295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181282761537702,"score_gpt":0.2569732443269468,"score_spread":0.2388449681731766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}