{"id":"W3047418653","doi":"10.1002/hep.31488","title":"A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Primary sclerosing cholangitis; Fibrosis; Signature (topology); Transcriptome; Medicine; Disease; Internal medicine; Gene signature; Pathology; Biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003217492,0.0002006381,0.0002870839,0.0005279535,0.0001617312,0.0003541714,0.0001087471,0.0001818074,0.0008106121],"category_scores_gemma":[0.0006727332,0.0001415025,0.0002939443,0.0004699747,0.0001976509,0.0001373658,0.0002009367,0.0002575407,0.0001492005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134029,"about_ca_system_score_gemma":0.0002400425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664849,"about_ca_topic_score_gemma":0.001262168,"domain_scores_codex":[0.9998026,0.00004651833,0.00001180396,0.00005399571,0.00005049271,0.00003448476],"domain_scores_gemma":[0.999516,0.0001152584,0.0002227264,0.00003120819,0.00004937224,0.0000654557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001974318,0.0001287066,0.8329762,0.00009402711,0.000208727,0.000306765,0.0001577211,0.001738621,0.1447974,0.0001799341,0.0003529443,0.01708475],"study_design_scores_gemma":[0.0000149954,0.0001837113,0.9916527,0.00000663942,0.00007109874,0.0003431709,0.00006674244,0.003809418,0.003508432,0.0001465245,0.000190023,0.000006544881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990381,0.00009504346,0.0003907549,0.00002512991,0.000001638879,0.000007916901,0.0002706777,0.000008357418,0.0001623047],"genre_scores_gemma":[0.9989592,0.00004746157,0.0004235645,0.00001550538,0.000004549235,0.00001035242,0.0004349348,0.000003490265,0.0001010016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008106121,"threshold_uncertainty_score":0.002711833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181282761537702,"score_gpt":0.2569732443269468,"score_spread":0.2388449681731766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}