{"id":"W3047427106","doi":"10.1126/sciadv.aba8415","title":"Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; Neuroendocrine Tumor Research Foundation","keywords":"Death-associated protein 6; Endogeny; Gene silencing; Endogenous retrovirus; In vivo; Biology; Cell biology; Neuroscience; Genetics; Transcription factor; Nuclear protein; Gene; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003048983,0.0003103033,0.0002236845,0.0002836145,0.0002917334,0.0005505193,0.0004033118,0.0002987227,0.001825922],"category_scores_gemma":[0.0002831784,0.0001662577,0.0002193749,0.0001318279,0.0004160816,0.0003347436,0.0004015627,0.0007222098,0.0004819696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003618485,"about_ca_system_score_gemma":0.0002322314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248747,"about_ca_topic_score_gemma":0.0007571083,"domain_scores_codex":[0.999736,0.00004504341,0.00003663491,0.00007212386,0.00006628173,0.00004401941],"domain_scores_gemma":[0.9996251,0.0001012367,0.00007793436,0.000107588,0.00002527202,0.00006291461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002819592,0.000008216429,0.0001740902,0.000008307416,0.000002771576,0.00003128699,0.000009411121,0.00005907343,0.9982454,0.0004711699,0.00001568492,0.000946398],"study_design_scores_gemma":[0.000007076973,0.0000690261,0.001374525,0.000004257276,0.000007295912,0.0003753281,0.0000190542,0.001194694,0.9943942,0.0001334002,0.002417285,0.0000037835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793057,0.0007627265,0.01514734,0.00009964116,0.00004264728,0.00003672834,0.0004473693,0.0002470431,0.003910867],"genre_scores_gemma":[0.9940288,0.0002149644,0.002295228,0.00001993536,0.000006561627,0.00001872483,0.0003566985,0.000076964,0.002982121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001825922,"threshold_uncertainty_score":0.006108344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934325688899479,"score_gpt":0.2494980824980775,"score_spread":0.2301548256090827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}