{"id":"W3047427106","doi":"10.1126/sciadv.aba8415","title":"Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; Neuroendocrine Tumor Research Foundation","keywords":"Death-associated protein 6; Endogeny; Gene silencing; Endogenous retrovirus; In vivo; Biology; Cell biology; Neuroscience; Genetics; Transcription factor; Nuclear protein; Gene; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590093,0.00008138007,0.00008000769,0.00004394829,0.0001162719,0.00003182097,0.0001632552,0.00003697869,0.000003898859],"category_scores_gemma":[0.0003771006,0.00007714182,0.00001495429,0.0002980167,0.0002341117,0.00001828511,0.0001043911,0.00005887018,0.000001425932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001416239,"about_ca_system_score_gemma":0.00008978268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001793578,"about_ca_topic_score_gemma":0.00003144419,"domain_scores_codex":[0.9990826,0.00002188433,0.000127154,0.0003673404,0.0001668746,0.0002341973],"domain_scores_gemma":[0.9997,0.00001563651,0.00004808477,0.00009167159,0.00003537036,0.0001092766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000140494,0.000006898926,0.01000766,0.000007732249,6.534207e-7,0.0000055691,0.0001230547,0.0008799437,0.9866002,0.00005104393,0.000001744677,0.002301459],"study_design_scores_gemma":[0.0001605566,0.0002742292,0.001728282,0.000005767862,0.000002062345,0.000001066745,0.0002026531,0.0004135957,0.9952399,0.0002145994,0.001655677,0.000101583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931,0.002076763,0.003693875,0.00007739459,0.00006255304,0.00008619828,0.000005691941,0.000006405793,0.0008910602],"genre_scores_gemma":[0.9980666,0.0003397433,0.001369787,0.0001084675,0.00009028673,0.000003074765,0.000002179925,0.000005011622,0.00001482069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008639733,"threshold_uncertainty_score":0.3145752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934325688899479,"score_gpt":0.2494980824980775,"score_spread":0.2301548256090827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}