{"id":"W3047431181","doi":"10.1158/1538-7445.pedca19-b02","title":"Abstract B02: 5-Hydroxymethylcytosine profiles in circulating cell-free DNA are biomarkers of disease burden in children with neuroblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Neuroblastoma; Medicine; Biomarker; Pediatric cancer; Bone marrow; Epigenetics; Disease; Cell-free fetal DNA; Oncology; Cancer; Pathology; Internal medicine; Cancer research; Gene; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214143,0.0002148437,0.0002178984,0.0005552073,0.0002344059,0.0003373885,0.0001587162,0.0002681853,0.001390657],"category_scores_gemma":[0.0007845067,0.0001198412,0.000143046,0.0004752127,0.0002140542,0.000187328,0.0002385904,0.0003157962,0.000228481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003690895,"about_ca_system_score_gemma":0.0002429457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003118281,"about_ca_topic_score_gemma":0.002938533,"domain_scores_codex":[0.9998456,0.00002189584,0.00001466074,0.00004853564,0.00004028676,0.00002900172],"domain_scores_gemma":[0.9995689,0.0001237147,0.00015138,0.00002189832,0.00006570277,0.00006847022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003362533,0.00001757563,0.978256,0.00003008802,0.00002087002,0.0001554093,0.0001247919,0.0001551281,0.01727249,0.0000314685,0.000131921,0.003468081],"study_design_scores_gemma":[0.000005166849,0.0001349435,0.9919851,0.000007161183,0.00002407293,0.0009369608,0.0001942509,0.0002873071,0.005950822,0.0000284751,0.0004418888,0.000003769236],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986855,0.000243835,0.0002305686,0.00001972614,0.000001952504,0.000006456239,0.0005587644,0.000008726573,0.0002445768],"genre_scores_gemma":[0.9983745,0.0001091623,0.0005746962,0.00001629994,0.000002484592,0.00001092733,0.0007395736,0.000004287634,0.0001680015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003118281,"threshold_uncertainty_score":0.006200254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0441606395533976,"score_gpt":0.3401084513093612,"score_spread":0.2959478117559636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}