{"id":"W3047434078","doi":"10.1158/1538-7445.pedca19-b14","title":"Abstract B14: Pinpointing the origins of pediatric brain tumors using single-cell transcriptomic analysis","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; McGill University Health Centre; Jewish General Hospital","funders":"","keywords":"Biology; Transcriptome; Medulloblastoma; Wnt signaling pathway; Cell type; Forebrain; Carcinogenesis; Embryonic stem cell; Cell; Cancer research; Neuroscience; Genetics; Gene; Central nervous system; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618289,0.0002097773,0.0002658947,0.0007365179,0.0002938672,0.0005257482,0.0001760985,0.0002550295,0.002447772],"category_scores_gemma":[0.0002995272,0.0001277709,0.0002675364,0.0006461894,0.000177727,0.0001761481,0.0003114144,0.0003157757,0.001007397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281299,"about_ca_system_score_gemma":0.0003862099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002148508,"about_ca_topic_score_gemma":0.003931842,"domain_scores_codex":[0.9998852,0.00000513436,0.000006739027,0.00005125287,0.00002881968,0.0000227114],"domain_scores_gemma":[0.999833,0.00004177976,0.00003992656,0.00001412253,0.00004237614,0.00002873253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451373,0.00001409342,0.04770162,0.0001864266,0.00004155897,0.0003125276,0.0001637306,0.000680188,0.9334788,0.0002785595,0.0009512074,0.0160462],"study_design_scores_gemma":[0.00001356216,0.0001422438,0.573906,0.00008130743,0.0001345183,0.001897541,0.0006771683,0.009295096,0.3890212,0.0009659343,0.0238354,0.00002992885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390697,0.001523229,0.0279026,0.0001273572,0.0000354258,0.00008643773,0.02853165,0.0004848392,0.002238799],"genre_scores_gemma":[0.928889,0.00158143,0.04013418,0.0001592112,0.000029389,0.0002052576,0.02624269,0.0003132476,0.002445602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002447772,"threshold_uncertainty_score":0.008188665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029492899651488,"score_gpt":0.3732713470249165,"score_spread":0.2703220570597678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}