{"id":"W3047471655","doi":"10.21037/tlcr-19-346","title":"Impact of ALK variants on brain metastasis and treatment response in advanced NSCLC patients with oncogenic ALK fusion","year":2020,"lang":"en","type":"article","venue":"Translational Lung Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Seoul National University; National Natural Science Foundation of China","keywords":"Crizotinib; Medicine; Brain metastasis; Anaplastic lymphoma kinase; Internal medicine; Oncology; ALK inhibitor; Chemotherapy; Lung cancer; Sanger sequencing; Gastroenterology; Metastasis; Cancer; Mutation; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296214,0.0001620666,0.000294415,0.0002525411,0.00009136747,0.00001190013,0.00005267715,0.00004897911,0.0003038289],"category_scores_gemma":[0.0000763007,0.0001096593,0.00008006394,0.0005911764,0.000083541,0.0001118886,0.00001027141,0.0001619936,0.00000301542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000538768,"about_ca_system_score_gemma":0.001318922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014385,"about_ca_topic_score_gemma":0.0002174309,"domain_scores_codex":[0.9982129,0.000209178,0.0002362266,0.0003605393,0.0007040688,0.0002770275],"domain_scores_gemma":[0.9988076,0.0005303256,0.00004708026,0.0001532557,0.0002477767,0.0002139775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1397169,0.001830018,0.72621,0.0001507113,0.001680016,0.00007282438,0.006643073,0.003332989,0.011157,0.000260331,0.0004157715,0.1085303],"study_design_scores_gemma":[0.01685122,0.007675103,0.972544,0.0002498445,0.0001580188,0.000001626634,0.00005229859,0.001150415,0.000499846,0.0000303795,0.0006722881,0.0001150166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986908,0.0009078001,0.0000394264,0.009768031,0.0000129923,0.001384871,0.0004643901,0.00001288676,0.0005015945],"genre_scores_gemma":[0.9988032,0.0001653909,0.0003869322,0.0001261017,0.00002996175,0.0001798703,0.0001663643,0.00002652954,0.0001156533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.246334,"threshold_uncertainty_score":0.4471778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04920964493460971,"score_gpt":0.4434830573297769,"score_spread":0.3942734123951672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}