{"id":"W3047479028","doi":"10.1158/1538-7445.pedca19-b22","title":"Abstract B22: Cell state and lineage specification are controlled by epigenetic landscapes regulating the core transcriptional regulatory circuitry in pediatric neuroblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Neuroblastoma; Transcription factor; Enhancer; Cancer research; Cell biology; GATA3; Chromatin; Gene; Genetics; Cell culture","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007469735,0.0001223362,0.00016038,0.0001756762,0.0001581613,0.0002198108,0.0001230397,0.0001109871,0.001529365],"category_scores_gemma":[0.00008731013,0.0000963204,0.00009415128,0.0001173112,0.0001823371,0.00009524991,0.0001876832,0.0002448857,0.000258816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003506378,"about_ca_system_score_gemma":0.0002662836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001884251,"about_ca_topic_score_gemma":0.003217481,"domain_scores_codex":[0.9999195,0.000006833462,0.000005734668,0.00002662463,0.00002441288,0.00001688178],"domain_scores_gemma":[0.99994,0.000005739825,0.00002100919,0.000004769595,0.000009626443,0.00001877746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005619657,0.000003734882,0.001017204,0.00001015526,0.000001497851,0.00004296021,0.00001894088,0.00003224987,0.9978211,0.00007839742,0.00001768137,0.0008999971],"study_design_scores_gemma":[0.00001393468,0.0001640516,0.1442578,0.00001369603,0.00002602899,0.0008533606,0.0001881412,0.00101354,0.8488022,0.0001377144,0.004519583,0.000009881857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964563,0.0005668236,0.001482401,0.00002414604,0.000005912876,0.000007813777,0.0003825802,0.00003603615,0.001037913],"genre_scores_gemma":[0.9962044,0.0003669968,0.001049807,0.00001815088,0.000002558087,0.00001878943,0.0004360546,0.00001822414,0.001884949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884251,"threshold_uncertainty_score":0.005116224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07203216526159331,"score_gpt":0.3368644352514317,"score_spread":0.2648322699898383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}