{"id":"W3047515600","doi":"10.1016/j.atherosclerosis.2020.07.028","title":"Lomitapide for treatment of homozygous familial hypercholesterolemia: The Québec experience","year":2020,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute; Université du Québec à Chicoutimi; McGill University; Université de Montréal; Université Laval; McGill University Health Centre","funders":"Dow AgroSciences; Instituto Danone; Dairy Australia; Medicines Company; Flax Council of Canada; Canola Council of Canada; Amarin Corporation; Ionis Pharmaceuticals; Dairy Farmers of Canada; Regeneron Pharmaceuticals; Novartis; Chiesi Farmaceutici; AstraZeneca; Amgen; Pfizer; Fondation Leducq; Danone Institute North America; Sanofi; Merck","keywords":"Familial hypercholesterolemia; Medicine; Internal medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006317499,0.0004196675,0.0005663867,0.0002887694,0.001447534,0.000867577,0.0006320905,0.0009441935,0.002687165],"category_scores_gemma":[0.001069824,0.0001298851,0.0003920917,0.0008904113,0.0004722371,0.0004068711,0.0002969718,0.00118965,0.0003231899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009472559,"about_ca_system_score_gemma":0.009262826,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7963791,"about_ca_topic_score_gemma":0.9027037,"domain_scores_codex":[0.9996886,0.00008318368,0.00001898037,0.00003607115,0.0001002564,0.00007301749],"domain_scores_gemma":[0.999256,0.00009767393,0.00006071756,0.00002047689,0.000257405,0.0003077226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01094423,0.00490754,0.2188256,0.0008715456,0.001298299,0.0165134,0.002947408,0.001922879,0.01940969,0.005821719,0.07298367,0.6435541],"study_design_scores_gemma":[0.008203167,0.007407452,0.7430682,0.0009054235,0.001533551,0.009775767,0.002132911,0.003648521,0.002300946,0.0006898087,0.22007,0.0002641668],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8607286,0.05825098,0.001464663,0.02302415,0.0008447826,0.000346854,0.00208139,0.0001127795,0.05314583],"genre_scores_gemma":[0.9428772,0.0303764,0.002320216,0.007753415,0.0005244882,0.0001064478,0.001258988,0.00007154728,0.01471126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2036209,"threshold_uncertainty_score":0.40964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.066552303807905,"score_gpt":0.2857416877740859,"score_spread":0.2191893839661809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}