{"id":"W3047541588","doi":"10.1186/s13059-020-02106-z","title":"Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes","year":2020,"lang":"en","type":"article","venue":"Genome biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Institut National de la Recherche Agronomique; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale","keywords":"Euchromatin; Heterochromatin; Biology; Heterochromatin protein 1; Chromatin; Genetics; Insulator (electricity); CTCF; Gene; Histone; Genome; Evolutionary biology; Cell biology; Transcription factor; Physics; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102408,0.000218312,0.0002857092,0.00002987204,0.0001188548,0.00001987213,0.0004462496,0.0002001968,0.00003920372],"category_scores_gemma":[0.00009016088,0.0001672257,0.0001442596,0.0001173984,0.0002581932,0.000002422182,0.0002522506,0.000104871,0.000006721917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002100304,"about_ca_system_score_gemma":0.0001120684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002299446,"about_ca_topic_score_gemma":0.0000136572,"domain_scores_codex":[0.9985872,0.0001235633,0.0004238569,0.0004621402,0.0000773983,0.0003258759],"domain_scores_gemma":[0.9990122,0.00003809414,0.0002757288,0.0005120871,0.00005959133,0.0001022405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000585101,0.0000260422,0.008805096,0.00004138787,0.00007362227,0.00000249194,0.0001449773,0.0004659024,0.9895744,0.0001490636,0.00005320361,0.0006053556],"study_design_scores_gemma":[0.002414405,0.001010427,0.04803365,0.00003383092,0.0001344126,0.00002516541,0.0003216421,0.006182889,0.8763177,0.0007694496,0.06382027,0.0009361656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923096,0.002781965,0.003771246,0.000382088,0.0001516818,0.0002074572,0.0001656164,0.00001624433,0.0002140855],"genre_scores_gemma":[0.9963261,0.0001805384,0.002101287,0.0007175992,0.0002797642,0.00001344331,0.0003290293,0.0000339802,0.00001818854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1132567,"threshold_uncertainty_score":0.6819267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071181612895093,"score_gpt":0.2314593579042917,"score_spread":0.2207475417753408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}