{"id":"W3047556542","doi":"10.1358/dot.2020.56.8.3159186","title":"Golodirsen for Duchenne muscular dystrophy","year":2020,"lang":"en","type":"article","venue":"Drugs of today","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Exon skipping; Duchenne muscular dystrophy; Exon; Medicine; Dystrophin; Morpholino; Muscular dystrophy; Gene; Bioinformatics; Genetics; Antisense therapy; Internal medicine; Gene knockdown; Biology; Oligonucleotide; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003601206,0.0004207593,0.0004255757,0.0004497433,0.0002730443,0.0003886579,0.0002344255,0.0008307984,0.0106948],"category_scores_gemma":[0.0004039359,0.00005744219,0.0003641182,0.0002533626,0.0002324624,0.0003558146,0.0003645105,0.001442214,0.004190814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979275,"about_ca_system_score_gemma":0.0003805268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534201,"about_ca_topic_score_gemma":0.0008288745,"domain_scores_codex":[0.999858,0.00003652279,0.00001122601,0.00002417022,0.00004211701,0.00002800497],"domain_scores_gemma":[0.9998919,0.00002469575,0.00002373905,0.000005750759,0.00001872498,0.00003523372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003516761,0.0004588285,0.0009433018,0.001741699,0.000106891,0.00288773,0.0001360847,0.0002368906,0.02902093,0.01435986,0.1159532,0.8306379],"study_design_scores_gemma":[0.00124641,0.00270696,0.004028795,0.0004363744,0.00007560791,0.004920297,0.00004465809,0.0001191613,0.005893716,0.001824643,0.9786744,0.00002896981],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.09712142,0.6938637,0.005530341,0.05621586,0.009959509,0.0005850325,0.001924913,0.001572117,0.1332271],"genre_scores_gemma":[0.413173,0.2945254,0.01165019,0.04777746,0.005445892,0.0005432483,0.002970258,0.0002248252,0.2236897],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0106948,"threshold_uncertainty_score":0.03577769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0094307765891266,"score_gpt":0.2321511105201688,"score_spread":0.2227203339310422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}