{"id":"W3047568984","doi":"10.1158/1538-7445.pedca19-b25","title":"Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene <i>EWS-FLI1</i> reveals a targetable RNA G-quadruplex interaction","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Exon; RNA; Biology; RNA splicing; Transcription (linguistics); Fusion protein; Alternative splicing; Telomere; Ribonucleoprotein; RNA-binding protein; Messenger RNA; Molecular biology; Cell biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008039,0.0002079168,0.00011451,0.000106853,0.0001729439,0.0001769944,0.0001539132,0.0002090736,0.004139574],"category_scores_gemma":[0.00009315436,0.00007714301,0.0001955136,0.00005921786,0.0001540932,0.00007135053,0.0001432513,0.0004273166,0.00163983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003277442,"about_ca_system_score_gemma":0.0001268387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008251183,"about_ca_topic_score_gemma":0.001123745,"domain_scores_codex":[0.9998883,0.00001510613,0.000006425723,0.00002935304,0.00003783287,0.00002305522],"domain_scores_gemma":[0.9999223,0.00001551488,0.00001791073,0.000007992151,0.000008777971,0.00002747225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002149676,0.000008327066,0.00003422302,0.000005249862,9.79937e-7,0.00002559468,0.000005109689,0.00001395512,0.9996108,0.00005040029,0.00003434475,0.0001896074],"study_design_scores_gemma":[0.000007870122,0.0001297151,0.002683707,0.000003513345,0.000003833018,0.000205729,0.00001405632,0.0006797126,0.9939254,0.00004173094,0.00230193,0.000002902162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934939,0.0002946084,0.002616394,0.00008353267,0.0000382315,0.00002599218,0.0004204707,0.0001171768,0.002909708],"genre_scores_gemma":[0.9873537,0.0001225696,0.002486124,0.00007872454,0.00001108316,0.00002537219,0.001785356,0.00005870442,0.008078381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004139574,"threshold_uncertainty_score":0.01384825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1404505727666916,"score_gpt":0.4213511612875352,"score_spread":0.2809005885208435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}