{"id":"W3047585484","doi":"10.1158/1538-7445.pedca19-a35","title":"Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Vincristine; Neuroblastoma; Crizotinib; Etoposide; Doxorubicin; Cancer research; Medicine; Drug resistance; P-glycoprotein; Anaplastic lymphoma kinase; Gene knockdown; Multiple drug resistance; Pharmacology; Oncology; Chemotherapy; Internal medicine; Biology; Lung cancer; Cell culture; Cyclophosphamide","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002530128,0.0001760411,0.0002194533,0.0003542828,0.0001879242,0.0004129333,0.0001623831,0.0002521903,0.002459476],"category_scores_gemma":[0.0003787876,0.00008698105,0.000200439,0.0004653324,0.000221654,0.0001968675,0.0001768363,0.0003493693,0.0004260088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040887,"about_ca_system_score_gemma":0.0002847158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001776141,"about_ca_topic_score_gemma":0.001796663,"domain_scores_codex":[0.9997876,0.00001938949,0.00002353896,0.00007449712,0.00007475318,0.00002021968],"domain_scores_gemma":[0.9998145,0.00003150222,0.00007380131,0.00001818111,0.00003168765,0.00003036125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001828106,0.0001836458,0.3641208,0.0003353194,0.0002638917,0.002271065,0.0001390845,0.0005201767,0.583998,0.0004515675,0.003049313,0.04283896],"study_design_scores_gemma":[0.00005568171,0.0005233866,0.9302984,0.00002926646,0.0001778755,0.008349421,0.00009995484,0.001877077,0.05439985,0.0003317503,0.003844722,0.00001262829],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953611,0.001568172,0.0006635195,0.0001506864,0.00001210852,0.00001884484,0.001291975,0.00004268161,0.000890917],"genre_scores_gemma":[0.9978552,0.0003136567,0.0003807418,0.00005726451,0.00001112739,0.00001029104,0.001080588,0.000005359673,0.0002856615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002459476,"threshold_uncertainty_score":0.008227706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06580783660990208,"score_gpt":0.3672591913365227,"score_spread":0.3014513547266207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}