{"id":"W3047609062","doi":"10.1101/2020.08.04.235697","title":"Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; National Institutes of Health; University of Leeds","keywords":"Liver X receptor; Triple-negative breast cancer; Breast cancer; Liver X receptor alpha; Chemotherapy; Cancer research; P-glycoprotein; Medicine; Cancer; Internal medicine; Drug resistance; Cholesterol; Oncology; Nuclear receptor; Transcription factor; Biology; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009151,0.0001173693,0.0001790957,0.0001710066,0.0001426349,0.0002861163,0.00006009307,0.0001911224,0.002370092],"category_scores_gemma":[0.0001135641,0.00009668851,0.0001181249,0.0001227447,0.0001716791,0.00006922104,0.0001294349,0.0003814291,0.0005823832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100244,"about_ca_system_score_gemma":0.0001171279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006862542,"about_ca_topic_score_gemma":0.0005323287,"domain_scores_codex":[0.9999367,0.00001127813,0.000003739532,0.00001219005,0.00001509887,0.00002099205],"domain_scores_gemma":[0.9999368,0.00001110768,0.00001404456,0.000008894888,0.000006740961,0.00002236573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006790708,0.00005998954,0.008851016,0.0000186408,0.000009884196,0.0005188779,0.00005811342,0.00008678269,0.9863863,0.0001254229,0.0004859774,0.002719863],"study_design_scores_gemma":[0.0001583927,0.001478752,0.377005,0.0000168218,0.00006214567,0.007461265,0.0005878301,0.003790943,0.6017274,0.00055286,0.007141812,0.00001683351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984279,0.0003035868,0.0002066243,0.0001137113,0.00001524328,0.00000577522,0.0001730111,0.00002498548,0.0007291822],"genre_scores_gemma":[0.9976654,0.0001328691,0.00009974521,0.00004255791,0.00000828255,0.000007866523,0.0002726803,0.000009260053,0.001761332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370092,"threshold_uncertainty_score":0.007928729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032969065119935,"score_gpt":0.2350901611598936,"score_spread":0.2247604705086943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}