{"id":"W3047613394","doi":"10.1016/j.yexcr.2020.112215","title":"Manipulating the Mediator complex to induce naïve pluripotency","year":2020,"lang":"en","type":"review","venue":"Experimental Cell Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Generalitat de Catalunya; European Social Fund; European Regional Development Fund; Bruyère Research Institute","keywords":"Biology; Mediator; Cell biology; Induced pluripotent stem cell; Kinase; Enhancer; MAPK/ERK pathway; Embryonic stem cell; Genetics; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004874186,0.0008406614,0.0006037339,0.001423918,0.0001744019,0.0006604037,0.0006896878,0.0007775386,0.002461751],"category_scores_gemma":[0.0003473427,0.000311414,0.0003383779,0.0009678805,0.0004798339,0.0009027283,0.0006012128,0.001682094,0.00235033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147848,"about_ca_system_score_gemma":0.0006224461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006395836,"about_ca_topic_score_gemma":0.00106959,"domain_scores_codex":[0.9998925,0.00001479701,0.00001205012,0.0000245282,0.00004170708,0.00001447005],"domain_scores_gemma":[0.9998962,0.00004509326,0.00001649936,0.000006177997,0.00002393725,0.00001213206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007469884,0.00007609243,0.0001280998,0.009430269,0.00006831434,0.0002067957,0.00004507639,0.0006256689,0.02095265,0.01755195,0.02154008,0.9293002],"study_design_scores_gemma":[0.00001925437,0.00007242801,0.0003544823,0.0007898801,0.00003980558,0.0005433034,0.00001755793,0.0001088987,0.006840803,0.002287808,0.9889094,0.00001645038],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004060351,0.9947473,0.0009734068,0.0002464001,0.0002644901,0.00001253254,0.000035565,0.00002810387,0.003286025],"genre_scores_gemma":[0.002503431,0.9936665,0.000969102,0.0003018286,0.0000897986,0.00002286978,0.0000847717,0.000008015876,0.002353619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002461751,"threshold_uncertainty_score":0.008235395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1585083366037749,"score_gpt":0.4897245871732981,"score_spread":0.3312162505695231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}