{"id":"W3047620687","doi":"10.1158/1538-7445.pedca19-a20","title":"Abstract A20: Single-cell immune TCR repertoire profiling in the context of immunotherapy by using three 10x Genomics libraries","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"T-cell receptor; Biology; Immune system; Gene expression profiling; Repertoire; Gene; T cell; Computational biology; Gene expression; Molecular biology; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002908225,0.0005324594,0.000454385,0.000576484,0.0003180478,0.0007391456,0.0002941657,0.0004145585,0.003160176],"category_scores_gemma":[0.0002901982,0.0001873955,0.0005120219,0.0005430746,0.0002010492,0.000251781,0.0003211765,0.000608038,0.001287574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000261933,"about_ca_system_score_gemma":0.0002724002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006782612,"about_ca_topic_score_gemma":0.0006634611,"domain_scores_codex":[0.9996455,0.00004820513,0.0000190374,0.00008049437,0.0001267434,0.00007998649],"domain_scores_gemma":[0.9997824,0.00005992298,0.00003453554,0.00002301432,0.00004676309,0.00005340344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007491,0.00004211683,0.0003500169,0.00001494988,0.000004232235,0.00001368074,0.00001401365,0.0001797527,0.9973804,0.00002724877,0.0000636853,0.001809109],"study_design_scores_gemma":[0.000009042094,0.0002682711,0.006471301,0.000003397026,0.00001710226,0.0001020539,0.00002699252,0.002301082,0.9893957,0.00007209726,0.001322198,0.00001082153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528368,0.0002426609,0.04078724,0.0001287397,0.00003037895,0.0001149708,0.00328833,0.0008258095,0.001745156],"genre_scores_gemma":[0.8859848,0.0003884175,0.08680815,0.0002927294,0.00003143625,0.0004325249,0.01744327,0.0005929148,0.008025691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003160176,"threshold_uncertainty_score":0.01057184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08904234849044668,"score_gpt":0.3164002338438021,"score_spread":0.2273578853533554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}