{"id":"W3047622556","doi":"10.1101/2020.08.03.234989","title":"Binding Ligands that Straddle an Important Contact Site on the RBD of the Covid-19 Spike Protein","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Spike Protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Binding site; Straddle; Monoclonal antibody; Peptide; 2019-20 coronavirus outbreak; Spike (software development); Receptor; Chemistry; Virus; Antibody; Biology; Computational biology; Biochemistry; Medicine; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325404,0.0005250148,0.0005816244,0.0002436562,0.0003675537,0.0005832677,0.0004051414,0.0003572275,0.004474926],"category_scores_gemma":[0.0002081038,0.0001477818,0.0002166225,0.0001916682,0.0002819946,0.0001821277,0.0004427493,0.0005045463,0.001026318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696157,"about_ca_system_score_gemma":0.0003391307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006840723,"about_ca_topic_score_gemma":0.00102306,"domain_scores_codex":[0.9997808,0.00003864376,0.000007982947,0.00002969653,0.00009175867,0.00005105654],"domain_scores_gemma":[0.9999471,0.00001484376,0.000009291503,0.00000513435,0.00000548478,0.0000182009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007898077,0.000340018,0.0008666344,0.0001146478,0.00003240494,0.000277512,0.00003853283,0.0048003,0.9809703,0.0007518809,0.0008353029,0.01018268],"study_design_scores_gemma":[0.0001798302,0.001168562,0.001157702,0.00001308086,0.000043255,0.0004489885,0.00005322938,0.0120295,0.9777051,0.0003169632,0.006866079,0.00001767169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775575,0.001822023,0.01034726,0.0003166787,0.00008859214,0.0001588338,0.001032626,0.0004400017,0.008236491],"genre_scores_gemma":[0.9850793,0.0006225915,0.0091234,0.000186881,0.00001122363,0.00006949755,0.0009845988,0.00004265285,0.003879891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004474926,"threshold_uncertainty_score":0.01497018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06603684431580621,"score_gpt":0.3038092589892912,"score_spread":0.237772414673485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}