{"id":"W3047661378","doi":"10.1158/1538-7445.pedca19-ia21","title":"Abstract IA21: Blocking purine synthesis in cancer promotes response to immunotherapy","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunotherapy; Cancer; Cancer immunotherapy; Purine; Transversion; Cancer research; Mutagenesis; Purine analogue; Nucleotide; Mutation; Biology; Genetics; Medicine; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001973351,0.0002129799,0.0003256506,0.0002041913,0.0001139391,0.0003283801,0.0001849323,0.0003103136,0.005131348],"category_scores_gemma":[0.0002728423,0.00009996377,0.0001311671,0.0001374042,0.000146912,0.0001401272,0.0001410057,0.0006229823,0.0009560306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670425,"about_ca_system_score_gemma":0.0002770746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143573,"about_ca_topic_score_gemma":0.0005903787,"domain_scores_codex":[0.9998856,0.00002557419,0.000008805585,0.0000155772,0.00003130936,0.00003305603],"domain_scores_gemma":[0.999827,0.00004285308,0.0000410957,0.00001714832,0.0000175912,0.00005432092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001522469,0.0005149806,0.001173129,0.0001424021,0.00001890264,0.00007378492,0.00002515543,0.0003112531,0.959778,0.0003988456,0.001720321,0.03432079],"study_design_scores_gemma":[0.0002868935,0.007101846,0.02619052,0.00003947952,0.00008203159,0.0008428923,0.00003282758,0.001505751,0.9243199,0.0002943517,0.03928955,0.00001398718],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9694095,0.01297563,0.001787522,0.00127161,0.0004226711,0.0001259872,0.0006178743,0.0003540135,0.01303509],"genre_scores_gemma":[0.9890751,0.002277238,0.0009367593,0.0002025494,0.0001223088,0.00005135297,0.0003598942,0.0000317315,0.006943175],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005131348,"threshold_uncertainty_score":0.01716602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08735693364780281,"score_gpt":0.4168034415099978,"score_spread":0.329446507862195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}