{"id":"W3047705689","doi":"10.1016/j.isci.2020.101444","title":"Autoinhibition of TRPV6 Channel and Regulation by PIP2","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; Kidney Foundation of Canada","keywords":"TRPV6; Transient receptor potential channel; Chemistry; Biophysics; Transmembrane domain; Calcium; Helix (gastropod); Cell biology; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059717,0.000176329,0.0001582481,0.00007673918,0.0001347655,0.0001728898,0.0002457631,0.0002110927,0.0008463032],"category_scores_gemma":[0.0001465992,0.0000769616,0.0002155004,0.0000565951,0.0002997109,0.0002837348,0.0002406681,0.0004729518,0.0001733969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162907,"about_ca_system_score_gemma":0.0001625467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003221778,"about_ca_topic_score_gemma":0.0002884593,"domain_scores_codex":[0.9999009,0.00001610233,0.000006998399,0.0000164895,0.00002021099,0.00003911435],"domain_scores_gemma":[0.9999487,0.00001036712,0.00001797563,0.000006457307,0.000004512912,0.00001186696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388023,0.00001289336,0.0001280914,0.00003192575,0.000002485942,0.00008109721,0.00001201532,0.00006036469,0.9985733,0.0002214802,0.00002752781,0.000709959],"study_design_scores_gemma":[0.00002434107,0.0001170401,0.008586898,0.000008954407,0.00001202787,0.0004319927,0.00004263248,0.002802839,0.9864747,0.00028509,0.001205178,0.000008259798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936478,0.001246629,0.003387635,0.0001061877,0.00002629067,0.000009287866,0.00006314099,0.00004045152,0.001472652],"genre_scores_gemma":[0.998045,0.0004764081,0.000726929,0.00005383924,0.000007667531,0.00001696392,0.00007267469,0.000006999306,0.0005935155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008463032,"threshold_uncertainty_score":0.002831161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457051756715965,"score_gpt":0.2436882223231768,"score_spread":0.2091177047560172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}