{"id":"W3047705689","doi":"10.1016/j.isci.2020.101444","title":"Autoinhibition of TRPV6 Channel and Regulation by PIP2","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; Kidney Foundation of Canada","keywords":"TRPV6; Transient receptor potential channel; Chemistry; Biophysics; Transmembrane domain; Calcium; Helix (gastropod); Cell biology; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008017904,0.00005352464,0.0000689216,0.00002495316,0.00008730043,0.00001996446,0.00009359643,0.00002626029,0.00003500497],"category_scores_gemma":[0.0001502756,0.00004355578,0.00001671465,0.000303217,0.0002058512,0.0002138786,0.00004147715,0.00004105219,0.00001605631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004717187,"about_ca_system_score_gemma":0.00001502192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004844117,"about_ca_topic_score_gemma":2.251958e-7,"domain_scores_codex":[0.9993054,0.00002580405,0.0001087447,0.0002453207,0.0002028087,0.0001119145],"domain_scores_gemma":[0.9997727,0.00003148831,0.00006477088,0.00004369862,0.00001621918,0.0000711396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004324759,0.00001039823,0.000007333806,0.000008404293,1.062914e-7,3.51934e-7,0.000603446,0.00007602515,0.9949912,0.0007457321,0.001650645,0.001902013],"study_design_scores_gemma":[0.0001111339,0.00008470042,0.0001441451,0.00001050521,0.000001055083,0.000003184372,0.0000532777,0.02841302,0.9691147,0.0003741654,0.001630062,0.00006005059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988702,0.00008948474,0.004819721,0.00422403,0.0002494859,0.0001270244,0.00001646125,0.00005015918,0.001721639],"genre_scores_gemma":[0.9989714,0.00003073085,0.00005310816,0.0006016722,0.00003926205,0.000001461494,7.83265e-7,0.000003560162,0.0002980074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02833699,"threshold_uncertainty_score":0.1776153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457051756715965,"score_gpt":0.2436882223231768,"score_spread":0.2091177047560172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}