{"id":"W3047734088","doi":"10.1038/s41598-020-70325-2","title":"Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; Ontario Centres of Excellence","keywords":"Vesicular stomatitis virus; Trehalose; In vivo; Immunogenicity; Excipient; Viral vector; Vector (molecular biology); Virology; Chemistry; Biology; Immune system; Virus; Biotechnology; Immunology; Chromatography; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006468793,0.0001520959,0.0001857299,0.00006273881,0.0001285954,0.0001209881,0.0001878437,0.0001203544,0.0004540226],"category_scores_gemma":[0.0001781242,0.0001323754,0.00005755984,0.000331229,0.0001419121,0.00001067968,0.0002144122,0.0001417588,0.000009510804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001946358,"about_ca_system_score_gemma":0.0002006045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001776348,"about_ca_topic_score_gemma":0.00008533907,"domain_scores_codex":[0.9980882,0.00009326954,0.0003074293,0.0008681368,0.0002787933,0.0003641625],"domain_scores_gemma":[0.9990262,0.00001039739,0.0001252474,0.0005629695,0.0001328696,0.0001423448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008504398,0.00004809845,0.002459879,0.000008248608,0.00003419808,0.0001194149,0.0002816091,0.00001882319,0.9899392,0.000001456742,0.004861625,0.001377001],"study_design_scores_gemma":[0.0004191014,0.0006725132,0.0024541,0.000006750241,0.000004545488,0.00002559903,0.00009981175,0.00003315374,0.9697351,0.0001423442,0.02624639,0.000160614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965274,0.0006835915,0.00002357531,0.0008738719,0.0002885599,0.0003371268,0.00001014667,0.00001808334,0.0012377],"genre_scores_gemma":[0.9977095,0.00006181279,0.0001080192,0.0003794538,0.00005995973,0.00002327327,0.00004072532,0.0000187259,0.001598528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02138477,"threshold_uncertainty_score":0.5398111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719030507273474,"score_gpt":0.2718934187393346,"score_spread":0.2547031136665999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}