{"id":"W3047734088","doi":"10.1038/s41598-020-70325-2","title":"Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; Ontario Centres of Excellence","keywords":"Vesicular stomatitis virus; Trehalose; In vivo; Immunogenicity; Excipient; Viral vector; Vector (molecular biology); Virology; Chemistry; Biology; Immune system; Virus; Biotechnology; Immunology; Chromatography; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583166,0.0002958589,0.0002183692,0.0001544008,0.00005991591,0.0001623109,0.0001259003,0.0002067917,0.001193581],"category_scores_gemma":[0.0001251814,0.00008418801,0.0001781945,0.0001195547,0.0001947398,0.000157759,0.00008164122,0.0003583606,0.0002403503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336269,"about_ca_system_score_gemma":0.0001350592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003686372,"about_ca_topic_score_gemma":0.0005186094,"domain_scores_codex":[0.9999079,0.00001341049,0.000007251165,0.00002329286,0.00003010128,0.00001803945],"domain_scores_gemma":[0.9999319,0.00001171741,0.00002310794,0.000007989164,0.00001493433,0.00001035057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003007867,0.000008660048,0.0000478336,0.00001444836,0.000002758162,0.000008585463,0.000004984993,0.00003200832,0.9992273,0.00002743612,0.00001061508,0.000585251],"study_design_scores_gemma":[0.000003676114,0.0003772929,0.001244855,0.000003903442,0.00000937258,0.00009391661,0.000009981029,0.0002853418,0.9969838,0.00002835843,0.0009571024,0.000002370291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913471,0.001528575,0.005727164,0.00004973295,0.0000510251,0.00003026807,0.0002342535,0.00007369482,0.0009581521],"genre_scores_gemma":[0.9935888,0.000796671,0.002920297,0.00003142991,0.000008474765,0.00001847449,0.0003802198,0.00003681151,0.002218802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193581,"threshold_uncertainty_score":0.003992915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719030507273474,"score_gpt":0.2718934187393346,"score_spread":0.2547031136665999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}