{"id":"W3047744272","doi":"10.1007/s12192-020-01146-5","title":"Sex differences in COVID-19 mortality: opportunity to develop HSP27 (HSPB1) immunotherapy to treat hyper-inflammation?","year":2020,"lang":"en","type":"letter","venue":"Cell Stress and Chaperones","topic":"Optimism, Hope, and Well-being","field":"Psychology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Inflammation; Immunotherapy; Immunology; Medicine; Photoaging; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Hsp27; Virology; Biology; Heat shock protein; Immune system; Hsp70; Internal medicine; Dermatology; Disease; Genetics; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007435711,0.0002393313,0.0004746248,0.0002586394,0.0002832148,0.0007737184,0.0003149519,0.0005622834,0.007595665],"category_scores_gemma":[0.001394438,0.0001253523,0.0005200895,0.0003068788,0.0003986519,0.0006111204,0.000311758,0.001263648,0.001139843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003391097,"about_ca_system_score_gemma":0.000827141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525449,"about_ca_topic_score_gemma":0.003188707,"domain_scores_codex":[0.9997351,0.00008616717,0.00001255204,0.00004812441,0.00003975544,0.00007827329],"domain_scores_gemma":[0.9995654,0.00009135233,0.00009660283,0.00002644203,0.00009141019,0.0001286861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003023698,0.0008091072,0.2114484,0.001796597,0.0005756244,0.002130531,0.0008626226,0.0002808726,0.01142121,0.009287635,0.07310978,0.685254],"study_design_scores_gemma":[0.0003896815,0.003657801,0.6682847,0.001971841,0.001054396,0.007717497,0.00356533,0.0007956708,0.004666055,0.02030538,0.2874329,0.0001586568],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.2887226,0.5397435,0.003127368,0.1291136,0.006095829,0.00009107453,0.002787698,0.0001577911,0.03016046],"genre_scores_gemma":[0.7303844,0.2155795,0.002062545,0.02669096,0.006659818,0.0001348993,0.001994651,0.00007258548,0.01642071],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.007595665,"threshold_uncertainty_score":0.02541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05832362001196945,"score_gpt":0.3083906151692302,"score_spread":0.2500669951572607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}