{"id":"W3047744272","doi":"10.1007/s12192-020-01146-5","title":"Sex differences in COVID-19 mortality: opportunity to develop HSP27 (HSPB1) immunotherapy to treat hyper-inflammation?","year":2020,"lang":"en","type":"letter","venue":"Cell Stress and Chaperones","topic":"Optimism, Hope, and Well-being","field":"Psychology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Inflammation; Immunotherapy; Immunology; Medicine; Photoaging; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Hsp27; Virology; Biology; Heat shock protein; Immune system; Hsp70; Internal medicine; Dermatology; Disease; Genetics; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001744609,0.0006245669,0.0008957124,0.000272941,0.0002382671,0.0002161916,0.0005378894,0.0005735925,0.002281037],"category_scores_gemma":[0.00006759141,0.0005624581,0.00008491909,0.000371712,0.0001010895,0.0001033167,0.0001685194,0.0007463054,0.0001488219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008854982,"about_ca_system_score_gemma":0.0002451646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046458,"about_ca_topic_score_gemma":0.0003158959,"domain_scores_codex":[0.9970849,0.0003127814,0.0006368145,0.0009854567,0.0003366244,0.000643393],"domain_scores_gemma":[0.99834,0.0002202279,0.0001791097,0.0005682551,0.00007110221,0.0006213142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004070628,0.0003808369,0.06389288,0.002110149,0.0004639566,0.003134371,0.09571447,0.00003802005,0.000684861,0.0002764204,0.700274,0.132623],"study_design_scores_gemma":[0.002612283,0.0005919114,0.01828629,0.0004496217,0.0001607401,0.00002310599,0.009023461,0.00003469327,0.0009114423,0.0004488898,0.9650701,0.002387434],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6388811,0.001324649,0.0002657313,0.340265,0.001042495,0.001305016,0.0003125214,0.0001753884,0.01642811],"genre_scores_gemma":[0.2433729,0.002647321,0.0003051109,0.7226754,0.003095805,0.0006466347,0.00104303,0.0002071736,0.02600666],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3955083,"threshold_uncertainty_score":0.9996827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05832362001196945,"score_gpt":0.3083906151692302,"score_spread":0.2500669951572607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}