{"id":"W3047744822","doi":"10.1021/acs.bioconjchem.0c00366","title":"The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy","year":2020,"lang":"en","type":"review","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; University of British Columbia","funders":"Networks of Centres of Excellence of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; European Commission; Horizon 2020 Framework Programme; Government of Canada","keywords":"Nucleic acid; Genetic enhancement; Chemistry; Gene silencing; Gene delivery; Computational biology; Nanotechnology; RNA interference; Gene; RNA; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003230208,0.0004421658,0.0004072383,0.0005393264,0.0001445289,0.0004625432,0.0002861379,0.0007860939,0.001548801],"category_scores_gemma":[0.0003011091,0.0001883442,0.0003441942,0.0003349217,0.0002573078,0.0006431926,0.0004058412,0.0008823923,0.001238793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003814908,"about_ca_system_score_gemma":0.0003779235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928344,"about_ca_topic_score_gemma":0.0004223325,"domain_scores_codex":[0.9998145,0.00003669121,0.00001643749,0.00003568158,0.00007604379,0.00002066228],"domain_scores_gemma":[0.9999189,0.00002915054,0.00001786226,0.000004360715,0.00002165119,0.000007916199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001350455,0.00009261141,0.0003782196,0.01173661,0.000123028,0.0008006687,0.000282626,0.001777041,0.5385512,0.03024516,0.0257842,0.3900936],"study_design_scores_gemma":[0.00002010461,0.0002623902,0.0005894655,0.0005793855,0.00006617172,0.001539774,0.00004943396,0.001150493,0.1214488,0.004314915,0.8699387,0.00004018956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01304841,0.9274809,0.03140869,0.002091287,0.001436686,0.0001490773,0.0002458073,0.0003292472,0.02380988],"genre_scores_gemma":[0.1029172,0.8520462,0.02448929,0.002343898,0.00117051,0.0002784726,0.0004986433,0.00009001065,0.01616577],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001548801,"threshold_uncertainty_score":0.005181253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875017481696296,"score_gpt":0.3075916859430831,"score_spread":0.2688415111261201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}